Application of circRNA expression profile for the diagnosis of gastric cancer：a Meta-analysis
XU Shiyou CHEN Yanbin YUAN Pengfei LEI Liangliang LIU Dechun▲
Department of Gastrointestinal Surgery, and College of Clinical Medical College He′nan University of Science and Technology the First Affiliated Hospital of He′nan University of Science and Technology, He′nan Province, Luoyang 471003, China
Abstract：Objective To explore the value of circRNA expression profile in the diagnosis of gastric cancer by meta-analysis. Methods Chinese and English literatures on circRNA used for gastric cancer diagnosis were searched from Datebase of Wanfang, CNKI, PubMed and EMBASE from the time of building database to November 30, 2018. The quality of the literature was evaluated by quality assessment of diagnostic accuracy studies-2 (QUADAS-2); the overall data was combined using Stata 12.0; sensitivity analysis and meta-regression analysis were conducted to explore the sources of heterogeneity; circRNA expression profile used for the diagnosis of gastric cancer was detected by Deek′s funnel plot. Results A total of 12 eligible articles were enrolled. The total area under the curve (AUC) for diagnosis of gastric cancer by circRNA expression profile was 0.80. Corresponding sensitivity, specificity, diagnostic odds ratio (DOR) and 95%CI were 0.69 (95%CI: 0.66-0.71, P = 0.000), 0.73 (95%CI: 0.70-0.75, P = 0.000) and 7.42 (95%CI: 6.01-9.16, P = 0.294), respectively. Subgroup analysis showed that the AUC value of circRNA expression profile in plasma (0.84) was higher than that in tissue (0.78), but there was no statistical difference in Z-test (P = 0.236). Conclusion CircRNA expression profile has relatively high diagnostic value in gastric cancer and it is expected to become an auxiliary diagnostic indicator for gastric cancer.
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