Abstract：Objective To investigate the value of trigeminal somatosensory evoked potential (TSEP) in the early diagnosis of blepharospasm. Methods From November 2016 to June 2017, 73 cases with early non-spasmodic symptoms of blepharospasm admitted to the Third People's Hospital of Dalian were selected and 30 cases of healthy people as group Ⅱ and groupⅠ respectively. According to the testing results of TSEP, patients of group Ⅱ were further divided into two subgroups, 40 cases (group Ⅱa) with abnormal TSEP and 33 cases (group Ⅱb) with the normal TSEP. The peak-to-peak amplitude of N13-P19, P19-N30, N13/P19 and P19/N30 at locus C (5,6), F (5,6) peak-to-peak amplitude at sites N13′-P19′, P19′- N30′, N13′/P19′ /N30′ in each group were statistically analyzed. One year of follow-up, the incidence of blepharospasm group Ⅱa and group Ⅱb were observed. Results Compared with group Ⅰ, P19/N30 peak-to-peak amplitude and P19′/N30′ peak-to-peak amplitude of goup Ⅱ were increased, the differences were statistically significant (P ＜ 0.05), the other indicators showed no statistically significant difference (P ＞ 0.05). Compared with group Ⅱb, P19/N30 peak-to-peak amplitude and P19′/ N30′ peak-to-peak amplitude of group Ⅱa were increased, the differences were highly statistically significant (P ＜ 0.01), the other indicators showed no statistically significant difference (P ＞ 0.05). One year of follow-up, the incidence of blepharospasm of groupⅡa was higher than group Ⅱb, the difference was statistically significant (P ＜ 0.05). Conclusion TSEP can detect increased excitability of nerve nucleus group in the early stage of blepharospasm, providing basis for early diagnosis of blepharospasm, and can be popularized in clinical work.
2019, Vol. 16 
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