Abstract：Molecular pathology is a new frontier interdisciplinary subject in modern medicine. It has wide clinical practicability and is often used in clinical staging of cancer and diagnosis of infectious diseases. Developing this course in medical colleges and universities is not only to meet the needs of teachers and students, but also to conform to the development and progress of this subject. The purpose of this study is to explore the significance and teaching methods of molecular pathology elective course for medical undergraduates. The study is carried out from three aspects: the urgency of the course, the implementation at home and abroad, and the problems and solutions in the teaching process. The study is based on training guidelines formulated by the National Certification Organization for Clinical Laboratory Sciences of the United States and the cancer diagnosis and treatment standards formulated by the Chinese Society of Clinical Oncology in conjuction with teaching practice.
欧霞 杨志鸿 邹英鹰 王燮 刘兰 申丽娟▲. 将分子病理学纳入医学本科生选修课的教学探讨[J]. 中国医药导报, 2019, 16(25): 65-68.
OU Xia YANG Zhihong ZOU Yingying WANG Xie LIU Lan SHEN Lijuan▲. Discussion on the teaching of molecular pathology as an elective course for medical undergraduates. 中国医药导报, 2019, 16(25): 65-68.
[1] Zhou R，Wei Y，Sciacovelli L，et al. A pilot study for establishing quality indicators in molecular diagnostics according to the IFCC WG-LEPS initiative：preliminary findings in China [J]. Clin Chem Lab Med，2018.[Epub ahead of print].
[2] Roy S，Coldren C，Karunamurthy A，et al. Standards and guidelines for validating next-generation sequencing bioinformatics pipelines：a joint recommendation of the Association for Molecular Pathology and the College of American Pathologists [J]. J Mol Diagn，2018，20（1）：4-27.
[3] Li MM，Datto M，Duncavage EJ，et al. Standards and guidelines for the interpretation and reporting of sequence variants in cancer：a joint consensus recommendation of the Association for Molecular Pathology，American Society of Clinical Oncology，and College of American Pathologists [J]. J Mol Diagn，2017，19（1）：4-23.
[4] Taylor S，Bennett KM，Deignan JL，et al. Molecular pathology curriculum for medical laboratory scientists：a report of the association for molecular pathology training and education committee [J]. J Mol Diagn，2014，16（3）：288-296.
[5] Maxwell P，Salto-Tellez M. Training in molecular cytopathology testing [J]. Cytopathology，2018，29（1）：5-9.
[6] Panagiotou N. Forces driving change in medical diagnostics [J]. Clin Chim Acta，2013，415：31-34.
[7] 来茂德.病理学高级教程[M].北京：人民军医出版社，2013：975.
[8] Buja LM，Barth RF，Krueger GR，et al. The Importance of the autopsy in medicine：perspectives of pathology colleagues [J]. Acad Pathol，2019，6：2374289519834041.
[9] Moore DA，Young CA，Morris HT，et al. Time for change：a new training programme for morpho-molecular pathologists? [J]. J Clin Pathol，2018，71（4）：285-290.
[10] Lett D. National standards for forensic pathology training slow to develop [J]. CMAJ，2007，177（3）：240-241.
[11] Clay MR，Fisher KE. Bioinformatics education in pathology training：current scope and future direction [J]. Cancer Inform，2017，16：1176935117703389.
[12] Damewood RB，Blair PG，Park YS，et al. “Taking training to the next level”：the American College of Surgeons Committee on residency training survey [J]. J Surg Educ，2017，74（6）：e95-e105.
[13] 唐运莲，程爱兰，甘润良.将分子病理学进展引入病理学教学的探索[J].基础医学教育，2014，16（10）：797-800.
[14] Zhu XL，Gao LM，Li F，et al. Clinical and pathological characteristic of metastatic malignant mesothelioma initially diagnosed by lymph node biopsy [J]. Pathol Res Pract，2017，213（6）：598-605.
[15] Kurz CM，Moosdijk SV，Thielecke H，et al. Towards a cellular multi-parameter analysis platform：fluorescence in situ hybridization （FISH） on microhole-array chips[J]. Conf Proc IEEE Eng Med Biol Soc，2011，2011：8408-8411.
[16] Ballard ZS，Brown C，Ozcan A. Mobile technologies for the discovery，analysis，and engineering of the global microbiome [J]. ACS Nano，2018，12（4）：3065-3082.
[17] 马志萍，王雯，李新霞.分子病理学课程教学方法的初步探讨[J].课程教育研究，2017，26：243-244.
[18] Bankowski MJ, Cankovic M, Dunlap J，et al. Molecular Diagnostic Assay Validation -- Update to the 2009 AMP Molecular Diagnostic Assay Validation White Paper [EB/OL]. https://www.amp.org/AMP/assets/File/resources/2015 03032014AssayValidationWhitePaper.pdf?pass=35
[19] Jennings LJ，Arcila ME，Corless C，et al. Guidelines for validation of next-generation sequencing-based oncology panels：a jointconsensus recommendation of the Association for Molecular Pathology and College of American Pathologists [J]. J Mol Diagn，2017，19（3）：341-365.
[20] Angione K，Gibbons M，Demarest S. An objective method for evaluating next-generation sequencing panels [J]. J Child Neurol，2018：883073818815036.[Epub ahead of print].
[21] 李玉林.病理学[M].9版.北京：人民卫生出版社，2018：95.
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