组蛋白赖氨酸甲基转移酶在糖尿病中的研究进展

摘要
图/表
参考文献(26)
相关文章 (15)

全文: PDF (600 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要糖尿病是一组由多病因引起的以慢性高血糖为特征的终身性代谢性疾病。长期血糖增高导致大血管、微血管受损并危及心、脑、肾、周围神经、眼、足等。表观遗传学中许多组蛋白修饰酶在糖尿病中发挥重要作用。越来越多的研究证实组蛋白赖氨酸甲基转移酶与糖尿病及其并发症的发生发展存在联系。组蛋白赖氨酸甲基转移酶不仅通过与一些转录因子的相互作用而影响胰岛素基因的表达，还可通过促进功能性β样细胞的转化来影响糖尿病的发生发展。组蛋白赖氨酸甲基转移酶还通过影响一些炎症因子，活性氧等参与到糖尿病并发症中。本文是对组蛋白赖氨酸甲基转移酶在糖尿病中研究进展的简要综述。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	包志伟杨天竹刘洋王志刚

关键词 ：组蛋白, 组蛋白甲基化, 赖氨酸甲基转移酶, 糖尿病

Abstract：Diabetes mellitus is a group of chronic hyperglycemia characterized by chronic metabolic diseases caused by multiple causes. Long-term elevated blood glucose results in damage to large blood vessels and microvessels and endangers the heart, brain, kidneys, peripheral nerves, eyes, feet, etc. Many histone modifying enzymes in epigenetics play important roles in diabetes mellitus. More and more studies have confirmed the relationship between histone lysine methyltransferase and diabetes mellitus and its complications. Histone lysine methyltransferase not only affects the expression of insulin gene through the interaction with some transcription factors, but also affects the occurrence and development of diabetes by promoting the transformation of functional beta cells. Histone lysine methyltransferase is also involved in diabetic complications by affecting inflammatory cytokines, reactive oxygen species, etc. This article is a brief review of the research progress of histone lysine methyltransferase in diabetes mellitus.

Key words： Histone Histone methylation Lysine methyltransferase Diabetes mellitus

基金资助:国家自然科学基金资助项目（81370523）。

通讯作者: 王志刚（1977.7-），男，博士，教授；研究方向：肝脏脂肪代谢的分子机制。

作者简介: 包志伟（1991.12-），女，哈尔滨医科大学（大庆）2016级生物化学与分子生物学专业在读硕士研究生；研究方向：脂类代谢的分子机制。

引用本文:

包志伟杨天竹刘洋王志刚. 组蛋白赖氨酸甲基转移酶在糖尿病中的研究进展[J]. 中国医药导报, 2019, 16(25): 45-48.
BAO Zhiwei YANG Tianzhu LIU Yang WANG Zhigang. Advanced in research of histone lysine methyltransferase and diabetes mellitus. 中国医药导报, 2019, 16(25): 45-48.

链接本文:

http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2019/V16/I25/45

[1] Ter Braak B，Siezen CL，Lee JS，et al. Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production [J]. Breast Cancer Res，2017，19（1）：14-28.
[2] Xue W，Huang J，Chen H，et al. Histone methyltransferase G9a modulates hepatic insulin signaling via regulating HMGA1. Biochimica et biophysica acta [J]. Molecular basis of disease，2018，1864（2）：338-346.
[3] Li MF，Zhang R，Li TT，et al. High Glucose Increases the Expression of Inflammatory Cytokine Genes in Macrophages Through H3K9 Methyltransferase Mechanism [J]. J Interferon Cytokine Res，2016，36（1）：48-61.
[4] 鲁铭，陶毅.组蛋白甲基化酶G9a对不同程度糖尿病足溃疡治疗干预的调控影响作用分析[J].标记免疫分析与临床，2018，25（5）：661-664.
[5] Schweizer S，Harms C，Lerch H，et al. Inhibition of histone methyltransferases SUV39H1 and G9a leads to neuroprotection in an in vitro model of cerebral ischemia [J]. J Cereb Blood Flow Metab，2015，35（10）：1640-1647.
[6] Zheng Q，Cao Y，Chen Y，et al. Senp2 regulates adipose lipid storage by de-SUMOylation of Setdb1 [J]. Mol Cell Biol，2018，10（3）：258-266.
[7] Yunlei D，Qiuling F，Xu W，et al. Transient High-Glucose Stimulation Induces Persistent Inflammatory Factor Secretion from Rat Glomerular Mesangial Cells via an Epigenetic Mechanism [J]. Cell Physiol Biochem，2018，49（5）：1747-1754.
[8] Liu X，Chen Z，Xu C，et al. Repression of hypoxia-inducible factor α signaling by Set7-mediated methylation [J]. Nucleic Acids Res，2015，43（10）：5081-5098.
[9] 宋秋艳.VEGF HIF-1α在糖尿病肾病中的表达及临床意义[J].糖尿病新世界，2016，19（10）：43-44.
[10] Li X，Li C，Li X，et al. Involvement of Histone Lysine Methylation in p21 Gene Expression in Rat Kidney In Vivo and Rat Mesangial Cells In Vitro under Diabetic Conditions [J]. J Diabetes Res，2016，2016（385）：32-42.
[11] Li Y，Reddy MA，Miao F，et al. Role of the histone H3 lysine 4 methyltransferase，SET7/9，in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation [J]. J Biol Chem，2008，283（39）：26771-26781.
[12] Wang W，Shi Q，Guo T，et al. PDX1 and ISL1 differentially coordinate with epigenetic modifications to regulate insulin gene expression in varied glucose concentrations [J]. Mol Cell Endocrinol，2016，15（5）：38-48.
[13] Chen X，Wu Q，Jiang H，et al. SET8 is involved in the regulation of hyperglycemic memory in human umbilical endothelial cells [J]. Acta Biochim Biophys Sin （Shanghai），2018，50（7）：635-642.
[14] Schaefer IM，Fletcher CD，Hornick JL. Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath tumors from histologic mimics [J]. Modern pathology，2016，29（1）：4-13.
[15] Oh JY，Choi GE，Lee HJ，et al. High Glucose-Induced Reactive Oxygen Species Stimulates Human Mesenchymal Stem Cell Migration Through Snail and EZH2-Dependent E-Cadherin Repression [J]. Cell Physiol Biochem，2018，46（5）：1749-1767.
[16] Iacovazzo D，Flanagan SE，Walker E，et al. MAFA missense mutation causes familial insulinomatosis and diabetes mellitus [J]. Proc Natl Acad Sci USA，2018，115（5）：1027-1032.
[17] Wang N，Zhu Y，Xie M，et al. Long Noncoding RNA Meg3 Regulates Mafa Expression in Mouse Beta Cells by Inactivating Rad21，Smc3 or Sin3α [J]. Cell Physiol Biochem，2018，45（5）：2031-2043.
[18] Fontcuberta-PiSunyer M，Cervantes S，Miquel E，et al. Modulation of the endocrine transcriptional program by targeting histone modifiers of the H3K27me3 mark [J]. Biochim Biophys Acta Gene Regul Mech，2018，1861（5）：473-480.
[19] Salguero-Aranda C，Tapia-Limonchi R，Cahuana GM，et al. Differentiation of Mouse Embryonic Stem Cells toward Functional Pancreatic β-Cell Surrogates through Epigenetic Regulation of Pdx1 by Nitric Oxide [J]. Cell Transplant，2016，25（10）：1879-1892.
[20] Rezania A，Bruin JE，Arora P，et al. Reversal of diabetes with insulin-producingcells derived in vitro from human pluripotent stem cells [J]. Nat Biotechnol，2014，32（11）：1121-1133.
[21] Thomas AA，Feng B，Chakrabarti S. ANRIL：A Regulator of VEGF in Diabetic Retinopathy [J]. Invest Ophthalmol Vis Sci，2017，58（1）：470-480.
[22] Ruiz MA，Feng B，Chakrabarti S. Polycomb repressive complex 2 regulates MiR-200b in retinal endothelial cells：potential relevance in diabetic retinopathy [J]. PLoS One，2015，10（4）：e0123987.
[23] 李婷婷，陈明云.H3K9me3参与调节高糖诱导大鼠胸主动脉平滑肌细胞增殖[J].现代生物医学进展，2016， 16（25）：4801-4804.
[24] Goldsworthy M，Absalom NL，Schr?觟ter D，et al. Mutations in Mll2，an H3K4 methyltransferase，result in insulin resistance and impaired glucose tolerance in mice [J]. PLoS One，2013，8（6）：e61870.
[25] Lee JE，Ge K. Transcriptional and epigenetic regulation of PPARgamma expression during adipogenesis [J]. Cell Biosci，2014，（4）：29-38.
[26] Shi S，Zhao L，Zheng L. NSD2 is downregulated in T2DM and promotes β cell proliferation and insulin secretion the transcripitionally regulation of PDX1 [J]. Mol Med Rep，2018，（3）：3513-3520.