Effects of a combination therapy with a compound Chinese medicine and an enteral nutrition powder in the treatment of mice with chronic obstructive pulmonary diseases
DENG Yicai1△ LIU Wenzhen2△ CHEN Zihan2,3 ZHANG Yaxin2 YAN Shufeng2 ZHENG Zhiling2,3 DONG Fang1 CHEN Zhuo2
1.Department of Respiration Medicine, the Second Hospital in Fuzhou Affiliated to Xiamen University, Fujian Province, Fuzhou 350007, China;
2.Division of Chemical Biology, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian Province, Fuzhou 350002;
3.Fuzhou No.1 High School, Fujian Province, Fuzhou 350100, China
Abstract：Objective To evaluate the validity and safety of a combination therapy with a compound Chinese medicine and an enteral nutrition powder ensure on chronic obstructive pulmonary diseases (COPD). Methods Among 96 male mice, 24 mice were randomly selected as a normal control group, the other 72 mice were induced as COPD mice after 60-day smoking. These COPD mice were then randomly divided into 3 groups: COPD positive group, Ensure treatment group (0.558 g/mL Ensure, 0.1 mL/10 g mice), combination therapy group (0.558 g/mL Ensure, 0.1 mL/10 g mice+2.5 g/mL traditional Chinese medicin, 0.06 mL/10 g mice). The weights of all mice were monitored during the whole experimental period. The serologic tests were carried out before and at different time points (2 weeks or 5 weeks) after the treatments began. Meanwhile, histological examinations of their lungs were performed. Results Compared with the normal control group mice, COPD mice showed a lower amount of serum albumin (P < 0.05) and a higher level of serum aminotransferase activity (P < 0.05) with a much slower rate in weight gaining.
邓宜材1△ 刘雯珍2△ 陈子晗2，3 张雅馨2 鄢树枫2 郑志凌2，3 董芳1 陈卓2 . 健脾益气复方中药联合肠内营养粉剂对慢性阻塞性肺疾病小鼠的治疗作用[J]. 中国医药导报, 2017, 14(14): 20-24.
DENG Yicai1△ LIU Wenzhen2△ CHEN Zihan2,3 ZHANG Yaxin2 YAN Shufeng2 ZHENG Zhiling2,3 DONG Fang1 CHEN Zhuo2. Effects of a combination therapy with a compound Chinese medicine and an enteral nutrition powder in the treatment of mice with chronic obstructive pulmonary diseases. 中国医药导报, 2017, 14(14): 20-24.
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2017, Vol. 14 
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