Abstract：Objective To analyze the relationship between 5,10-Methyleneterahydrofolate reductase gene polymorphisms (MTHFR A1298C) and cervical cancer in order to provide reliable data for better prevention and treatment of cervical cancer. Methods Database of Wanfang, CNKI and PubMed were searched from the time of building database to November 12, 2018, and a total of 7 articles about the relationship between MTHFR gene (A1298C) polymorphisms and cervical cancer were included in this Meta-analysis, including 823 cases and 1607 controls. The odds ratio (OR) and 95% confidence interval (CI) were calculated and to assess the associations, meanwhile, the sensitivity and publication bias were analyzed. Results There were significance associations in the comparison C vs. A (OR = 1.11, 95%CI: 1.02-1.22, P = 0.015), AC vs. AA (OR = 1.24, 95%CI: 1.02-1.52, P = 0.030) and (CC+AC) vs. AA (OR = 1.15, 95%CI: 1.03-1.29, P = 0.013). Conclusion MTHFR (A1298C) gene polymorphisms may increase the risk for cervical cancer.
周青 刘帅妹 张瑞金 石慧 林宁 吴玉璘 许豪勤. MTHFR基因多态性与宫颈癌关系的Meta分析[J]. 中国医药导报, 2019, 16(24): 99-102.
ZHOU Qing LIU Shuaimei ZHANG Ruijin SHI Hui LIN Ning WU Yulin XU Haoqin. Meta analysis of the association between MTHFR gene polymorphisms and cervical cancer. 中国医药导报, 2019, 16(24): 99-102.
[1] 徐晓明，尹春梅，严志淩，等.云南汉族人群TLR19基因多态性与宫颈癌发生及发展的相关性[J].贵州医科大学学报，2017，42（1）：1-5.
[2] 姜迪，张慧杰，张淑兰.亚甲基四氢叶酸还原酶基因多态性与宫颈癌关系[J].国际妇产科杂志，2015，42（1）：83-86.
[3] 张晓宇，方正美，姚应水.瘦素及其受体基因多态性与高血压相关性meta分析[J].中国临床药理学与治疗学，2017， 22（8）：910-916.
[4] Midgette AS，Wong JB，Beshansky JR，et al. Cost-effectiveness of streptokinase for acute myocardial infraction：a combined meta-analysis and decision analysis of the effects for of infarct location and of likelihood of infarction[J].Med Decis Making，1994，14（2）：108-117.
[5] 李天赋，周青，张翠，等.雌激素受体α基因多态性与男性不育关系的Meta分析[J].江苏大学学报：医学版，2015， 25（1）：57-61.
[6] Egger M，Davey Smith G.，Schneider M，et al. Bias in meta-analysis detected by a simple graphical test [J]. BMJ，1997，315（7109）：629-634.
[7] Kang S，Kim JW，Kang GH，et al. Polymorphism in folate-and methionine-metabolizing enzyme and aberrant CpG island hypermethylation in uterine cervical cancer [J]. Gynecol Oncol，2005，96（1）：173-180.
[8] Kohaar I，Thakur N，Salhan S，et al. Homocysteine levels are associated with cervical cancer independent of methylene terahydrofolate reductase gene（MTHFR）polymorphisms in India population [J]. Biomarkers，2010，15（1）：61-68.
[9] Tong SY，Kim MK，Lee JK，et al. Common polymorphisms in methylenetetrhydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasis and cervical cancer in women with low serum folate and vitamin B12 [J]. Cancer Causes Control，2011，22（（1）：63-72.
[10] 杨帆，周裕林，江雨，等.MTHFR基因多态性与宫颈癌发病的相关性研究[J].中国妇幼保健，2011，26（26）：4087-4089.
[11] Mostowska A，Myka M，Lianeri M，et al. Folate and choline metabolism gene variants and development of uterine cervical carcinoma [J]. Clin Biochem，2011，44（8/9）：596-600.
[12] 范岩峰，李建，许榕仙，等.MTHFR1298位点多态性及叶酸水平对宫颈癌发病的影响研究[J].四川大学学报：医学版，2014，45（2）：258-261.
[13] Hajiesmaeil M，Tafvizi F，Sarmadi S. The effect of meth-ylenetertrahydrofolate reductase polymorphisms on susceptibility to human papilloma virus infection and cervical cancer [J]. Infect Genet Evol，2016，46：1-6.
[14] 王勉勉，李喜梅，唐少华.MTHFR基因多态性与自然流产的关系[J].中国妇幼保健，2017，32（1）：92-94.
[15] 吴芳燕.56例不良妊娠MTHFR基因多态性分析[J].中外医学研究，2017，15（25）：58-59.
[16] 孙云晖，章婷，梁姗姗，等.MTHFR基因多态性与肺癌易感性的关系[J].临床肺科杂志，2018，23（4）：621-623.
[17] 胡韵仪，侯丽淳，季方茹，等.佳木斯地区MTHFR基因多态性与缺血性脑卒中的关系分析[J].黑龙江医药科学，2017，40（1）：89-91.
[18] 华知奋，黄彩梅，鲁衍强，等.MTHFR基因多态性与原因不明复发性流产的相关研究[J].国际检验医学杂志，2017，38（1）：16-17.
[19] 李引弟，岳红云，李华.孕期叶酸摄入与MTHFR基因多态性对产后抑郁的影响[J].中国妇幼健康研究，2017， 28（6）：632-635.
[20] 张仪，有凤芝，秦奇，等.MTHFR基因多态性及叶酸摄入量与不良孕产史关系研究[J].医药论坛杂志，2017（1）：66-69.
[21] 程筱雯，李洁，徐元宏.消化系统肿瘤与MTHFR基因多态性相关研究[J].安徽医科大学学报，2018，53（5）：782-783.
2019, Vol. 16 
京公网安备 11010502046598号