Systematic evaluation of the efficacy and safety of hemagglutinase sequential low molecular weight heparin for perioperative hemostasis in orthopedic surgery
WU Yue1 TIAN Liu2 CHEN Ying1 ZHOU Benhong1
1.Department of Pharmacy, Renmin Hospital of Wuhan University, Hubei Province, Wuhan 430060, China;
2.College of Pharmacy, Wuhan University, Hubei Province, Wuhan 430071, China
Abstract：Objective To systematically the effect of hemocoagulase sequential low molecular weight heparin treatment on hemorrhage and postoperative coagulation function of patients during perioperative period of orthopedic surgery. Methods Randomized controlled trials (RCTs) on the using of hemocoagulase during orthopedic surgery and low-molecular-weight heparin before surgery were searched from the building database to November 11, 2017 in CNKI, Wanfang Data, PubMed, and the references of all RCTs were further traced. After RCTs screening, data extraction, and quality evaluation carried out by two researchers according to the standards, RevMan 5.3.0 was used for Meta analysis. Results Six hundred and ninety-nine patients of 6 RCTs were included in 22 preliminary screening articles. The Meta analysis showed that, compared with control group, the intraoperative blood loss (SMD = -3.02, 95%CI [-4.44, -1.59], P ＜ 0.0001) and 24 h postoperative blood loss (SMD = -1.44, 95%CI [-2.50, -0.38], P = 0.008) of study group decreased significantly. There was no statistically significant difference in 24 h prothrombin time, partial thromboplastin time, fibrinogen (P > 0.05). Conclusion The therapeutic schedule of hemocoagulase sequential low molecular weight heparin during perioperative period of orthopedic surgery can reduce the peroperative bleeding and drainage 2 h after the operation, without increasing the incidence of adverse events, it has better security.
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2019, Vol. 16 
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