Abstract：Type 2 diabetes mellitus (T2DM) is a metabolic disease with increasing prevalence and mortality year by year. Its occurrence and development have brought enormous challenges to global public health. Metabonomics can detect metabolic changes in vivo before and after T2DM treatment and identify effective metabolites, so as to evaluate or predict the therapeutic effect, infer the therapeutic mechanism and provide new ideas for the treatment of T2DM. Therefore, this article reviews the metabonomics and its application in the treatment of T2DM with drug, bioactive food component, bariatric surgery and exercise, in order to provide reference for further research on the treatment of T2DM.
[1] World Health Organization. Global Report on Diabetes[EB/OL].[2018-12-16]. http：//apps.who.int/iris/bitstream/handle/10665/204871/9789241565257_eng.pdf
[2] Zheng Y，Ley SH，Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications [J]. Nat Rev Endocrinol，2017，14（2）：88-98.
[3] Dettmer K，Aronov PA，Hammock BD. Mass spectrometry-based metabolomics [J]. Mass Spectrom Rev，2010，26（1）：51-78.
[4] 许国旺.代谢组学——方法与应用[M].北京：科学出版社，2008：1-421.
[5] 蔡爽，孙博，李发美.代谢组学及其在药学中的应用[J].沈阳药科大学学报，2007，24（7）：445-450.
[6] Kaddurah-Daouk R，Weinshilboum RM. Pharmacometab-olomics：Implications for Clinical Pharmacology and Systems Pharmacology [J]. Clin Pharmacol Ther，2014，95（2）：154-167.
[7] Huo T，Xiong Z，Lu X，et al. Metabonomic study of biochemical changes in urinary of type 2 diabetes mellitus patients after the treatment of sulfonylurea antidiabetic drugs based on ultra-performance liquid chromatography/mass spectrometry [J]. Biomed Chromatogr，2015，29（1）：115-122.
[8] Breier M，Wahl S，Prehn C，et al. Immediate reduction of serum citrulline but no change of steroid profile after initiation of metformin in individuals with type 2 diabetes [J]. J Steroid Biochem Mol Biol，2017，174：114-119.
[9] Xu T，Brandmaier S，Messias AC，et al. Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes [J]. Diabetes Care，2015，38（10）：1858-1867.
[10] Doorn MV，Vogels J，Tas A，et al. Evaluation of metabolite profiles as biomarkers for the pharmacological effects of thiazolidinediones in Type 2 diabetes mellitus patients and healthy volunteers [J]. Br J Clin Pharmacol，2010，63（5）：562-574.
[11] Huo T，Cai S，Lu X，et al. Metabonomic study of biochemical changes in the serum of type 2 diabetes mellitus patients after the treatment of metformin hydrochloride [J]. J Pharm Biomed Anal，2009，49（4）：976-982.
[12] Cai S，Huo T，Xu J，et al. Effect of mitiglinide on Streptozotocin-induced experimental type 2 diabetic rats：a urinary metabonomics study based on ultra-performance liquid chromatography-tandem mass spectrometry [J]. J Chromatogr B Analyt Technol Biomed Life Sci，2009， 877（29）：3619-3624.
[13] Dong Y，Chen YT，Yang YX，et al. Urinary Metabolomic Profiling in Zucker Diabetic Fatty Rats with Type 2 Diabetes Mellitus Treated with Glimepiride，Metformin，and Their Combination [J]. Molecules，2016，21（11）：1446.
[14] Bao Y，Zhao T，Wang X，et al. Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers [J]. J Proteome Res，2009，8（4）：1623-1630.
[15] Ganesan K，Jayachandran M，Xu B. A critical review on hepatoprotective effects of bioactive food components [J]. Crit Rev Food Sci Nutr，2018，58（7）：1165-1229.
[16] 唐华丽，夏惠，王锋，等.枸杞多糖作用于2型糖尿病大鼠的血清代谢组学研究[J].食品科学，2017，38（13）：160-166.
[17] Zhou Y，Men L，Pi Z，et al. Fecal metabolomics of type 2 diabetic rats and treatment with Gardenia jasminoides Ellis based on mass spectrometry technique [J]. J Agric Food Chem，2018，66（6）：1591-1599.
[18] Man S，Ma J，Yao J，et al. Systemic Perturbations of Key Metabolites in Type 2 Diabetic Rats Treated by Polyphenol Extracts from Litchi chinensis Seeds [J]. J Agric Food Chem，2017，65（35）：7698-7704.
[19] Niu J，Pi ZF，Yue H，et al. Effect of 20（S）-ginsenoside Rg3 on streptozotocin-induced experimental type 2 diabetic rats：a urinary metabonomics study by rapid-resolution liquid chromatography/mass spectrometry [J]. Rapid Commun Mass Spectrom，2012，26（23）：2683-2689.
[20] Zhang S，Myracle A，Xiao K，et al. Metabolic Profiling of Green Tea Treatments in Zucker Diabetic Rats Using 1H NMR [J]. J Nutr Food Sci，2013，3（6）：239.
[21] 刘学军，齐德军，靳和平.胃转流手术治疗2型糖尿病临床分析[J].中国医药导报，2013，10（1）：37-38.
[22] Cefalu WT，Rubino F，Cummings DE. Metabolic surgery for type 2 diabetes：changing the landscape of diabetes care [J]. Diabetes Care，2016，39（6）：857-860.
[23] Samczuk P，Hady HR，Adamska-Patruno E，et al. In-and-Out Molecular Changes Linked to the Type 2 Diabetes Remission after Bariatric Surgery：An Influence of Gut Microbes on Mitochondria Metabolism [J]. Int J Mol Sci，2018，19（12）：3744.
[24] Luo P，Yu H，Zhao X，et al. Metabolomics Study of Roux-en-Y Gastric Bypass Surgery （RYGB） to Treat Type 2 Diabetes Patients Based on Ultraperformance Liquid Chromatography-Mass Spectrometry [J]. J Proteome Res，2016，15（4）：1288-1299.
[25] 李蕾，金其贯，胡振东，等.运动对2型糖尿病大鼠血清生物标记物时序性特征的代谢组分析[J].中国应用生理学杂志，2016，32（3）：255-259.
[26] Li X，Zhang H，Wei J，et al. Metabolomics studies on db/db diabetic mice in skeletal muscle reveal effective clearance of overloaded intermediates by exercise [J]. Anal Chim Acta，2018，1037：130-139.
[27] 李静静.基于代谢组学探究运动上调糖尿病大鼠海马突触可塑相关蛋白表达的可能机制[D].上海：上海体育学院，2018.
2019, Vol. 16 
京公网安备 11010502046598号