Research progress of traditional Chinese medicine based on metabolomics technology
YANG Bo YANG Qiang ZHANG Aihua WANG Xijun
National Research Center of Traditional Chinese Medicine Metabolism, Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China
Abstract：Metabolomics could explore the correlation between metabolites and physiological and pathological changes through high-throughput analysis of metabolites in the body, and clarify the interaction of complex systems and response to the outside body. Metabolomics emphasizes that the biochemical phenotype of the functional state of the organism as a whole that is highly similar to the holistic view of traditional Chinese medicine (TCM) theory. Metabolomics has its unique overall and dynamic expression characteristics coincides with the overall view of Chinese medicine and dialectical treatment diagnosis. The metabolomics technology is used to clarify the scientific effects related to the effectiveness mechanism, material basis and compatibility of TCM, to realize the organic integration of TCM theory and modern life science and technology, and fully understand the theoretical value of TCM theory and the practical value of TCM clinical experience. This paper explores the application of the holistic and dynamic characteristics of metabolomics to the specific practice of TCM, and solves key problems, such as the effect evaluation of Chinese herbal medicine, the interpretation of prescription compatibility, the relationship research of prescription and syndrome, and the discovery of syndrome biomarkers. It will provide the technical support for the evaluation of the effectiveness of TCM, the basis of prescription substances and the understanding essence of TCM syndromes.
杨波 杨强 张爱华 王喜军. 基于代谢组学技术的中医药研究进展[J]. 中国医药导报, 2019, 16(24): 24-28.
YANG Bo YANG Qiang ZHANG Aihua WANG Xijun . Research progress of traditional Chinese medicine based on metabolomics technology. 中国医药导报, 2019, 16(24): 24-28.
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