Abstract：Objective To investigate the expression and clinical pathological significance of SOX11 in glioblastoma. Methods A total of 264 cases of paraffin-embedded glioblastoma were collected from the Department of Pathology, Anhui Provincial Hospital from September 2010 to January 2017. Each sample was selected from the tumor area and the normal brain tissue of the tumor to make tissue chips. The expression of SOX11 was detected by immunohistochemistry and the relationship between SOX11 expression and clinicopathological features was analyzed. Results The total positive rate and strongly positive rate of SOX11 expression in glioblastoma was significantly higher than that in matched normal tissues of the tumor (P < 0.01). The expression of SOX11 was correlated with tumor diameter and Ki67 proliferation index (P < 0.01), but it was not related to the patient′s age, gender, single/multiple lesions (P > 0.05). Conclusion SOX11 is specifically expressed in glioblastoma and can be used as a marker for the pathological diagnosis of glioblastoma. The expression level of SOX11 may be related to tumor progression.
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2019, Vol. 16 
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