循环长链非编码RNA在结直肠癌中的研究进展

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摘要长链非编码RNA（lncRNA）在许多人类癌症中失调，包括结肠直肠癌（CRC），它是世界上第三大常见的癌症，与预后不良有关；与此同时，一些lncRNA作为抑癌基因或致癌基因参与CRC的发生发展，在诊断、治疗及预后方面具有重要价值。lncRNA可以以微泡、外泌体或蛋白质复合物的形式进入人体循环系统，形成稳定的循环lncRNA，且其浓度水平在健康受试者和患者之间存在差异，可以作为一种新颖、易于获取、无创的检测工具。本文简要回顾近年来关于循环lncRNA生物学特性的研究进展，着重分析了循环lncRNA作为结肠直癌筛查和预后监测生物标志物的潜在应用。

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	徐微1 刘雅雯1 龚爱华2 徐岷1

关键词 ：循环, 长链非编码RNA, 外泌体, 结直肠癌, 分子诊断

Abstract：Long noncoding RNA (lncRNA) is dysregulated in many human cancers, including colorectal cancer (CRC), which is the third most common cancer in the world and is associated with poor prognosis; at the same time, some lncRNAs are involved in the development of CRC as tumor suppressor genes or oncogenes and are of great value in diagnosis, treatment and prognosis. LncRNA can enter the human circulatory system in the form of microbubbles, exosomes or protein complexes, forming stable circulating lncRNA. Its concentration level is different between healthy subjects and patients, which can be used as a novel, affordable, lightly accessible, non-invasive detection tool. This article briefly reviews recent advances in the biological properties of circulating lncRNA, focusing on the potential applications of circulating lncRNA as a biomarker for colorectal cancer screening and prognosis monitoring.

Key words： Circulating Long noncoding RNA Exosome Colorectal cancer Molecular diagnosis

基金资助:国家自然科学基金资助项目（81672402）。

通讯作者: 徐岷（1974.10-），男，教授，博士研究生，主任医师，博士、硕士生导师，江苏大学附属医院消化内科主任，主要从事长链非编码RNA在消化道肿瘤中的研究。

作者简介: 徐微（1993.3-），女，江苏大学2016级消化内科专业在读硕士研究生，主要从事大肠癌的研究。

引用本文:

徐微1 刘雅雯1 龚爱华2 徐岷1. 循环长链非编码RNA在结直肠癌中的研究进展[J]. 中国医药导报, 2019, 16(23): 26-29,37.
XU Wei1 LIU Yawen1 GONG Aihua2 XU Min1. Research progress of circulating long chain non-coding RNA in colorectal cancer. 中国医药导报, 2019, 16(23): 26-29,37.

链接本文:

http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2019/V16/I23/26

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