注射用丹参多酚酸对缺血性脑卒中患者hs-CRP水平和血液流变参数的影响

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摘要目的观察注射用丹参多酚酸对缺血性脑卒中患者血清超敏C-反应蛋白（hs-CRP）水平和血液流变参数的影响。方法选取2016年1月～2018年12月河北省保定市第一中心医院收治的100例缺血性脑卒中患者作为研究对象，根据随机数字表法将患者分为对照组和观察组，每组各50例。对照组采用常规治疗，观察组在常规治疗基础上应用注射用丹参多酚酸进行治疗。观察两组患者治疗2周后的美国国立卫生研究院卒中量表（NIHSS）评分、血清hs-CRP水平及血液流变参数相关指标的变化。结果治疗后，两组患者NIHSS评分均低于治疗前，且观察组低于对照组，差异有高度统计学意义（P ＜ 0.01）。两组患者血清hs-CRP水平均低于治疗前，且观察组低于对照组，差异有统计学意义（P ＜ 0.05）。两组患者血浆黏度、全血黏度高切、全血黏度低切、红细胞比容均低于治疗前，且观察组低于对照组，差异有统计学意义（P ＜ 0.05）。结论注射用丹参多酚酸可有效改善缺血性脑卒中患者神经受损状况，降低血清hs-CRP水平，调节血液流变参数。

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	高爱民王宁钱倩刘永刚任翠剑齐伟静

关键词 ：注射用丹参多酚酸, 缺血性脑卒中, 超敏C-反应蛋白, 血液流变学

Abstract：Objective To observe the effect of Salvianolate Lyophilized Injection on the level of hypersensitive C-reactive protein (hs-CRP) and hemorheological parameters in patients with cerebral ischemic stroke. Methods From January 2016 to December 2018, 100 patients with cerebral ischemic stroke admitted to the First Central Hospital of Baoding were divided into the control group and the observation group according to the random number table, method with 50 cases in each group. The control group received conventional treatment, and the observation group was treated with Salvianolate Lyophilized Injection on the basis of conventional treatment. Changes in the National Institutes of health stroke scale (NIHSS) score, serum hs-CRP levels, and hemorheological parameters were observed after 2 weeks of treatment. Results After treatment, the NIHSS scores of the two groups were lower than those before treatment, and the NIHSS scores of the observation group were lower than the control group, the differences were highly statistically significant (P ＜ 0.01). The serum hs-CRP levels in the two groups were lower than those before treatment, and the serum hs-CRP levels in the observation group were lower than those in the control group, the differences were highly statistically significant (P ＜ 0.01). The plasma viscosity, whole blood viscosity were high, whole blood viscosity was low, and erythrocyte specific volume were lower than before treatment, and the observation goup was lower than control group and the difference was statistically significant (P ＜ 0.05). Conclusion Salvianolate Lyophilized Injection can effectively improve the neurological damage in patients with ischemic stroke, reduce serum hs-CRP levels and regulate hemorheological parameters.

Key words： Salvianolate Lyophilized Injection Cerebral ischemic stroke Hypersensitive C-reactive protein Hemorheological parameters

基金资助:河北省中医药管理局中医药类科研计划项目（2018433）。

引用本文:

高爱民王宁钱倩刘永刚任翠剑齐伟静. 注射用丹参多酚酸对缺血性脑卒中患者hs-CRP水平和血液流变参数的影响[J]. 中国医药导报, 2019, 16(22): 162-165.
GAO Aimin WANG Ning QIAN Qian LIU Yonggang REN Cuijian QI Weijing. Effect of Salvianolate Lyophilized Injection on hs-CRP level and hemorheological parameters in patients with cerebral ischemic stroke. 中国医药导报, 2019, 16(22): 162-165.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2019/V16/I22/162

[1] Hu X，De Silva TM，Chen J，et al. Cerebral vascular disease and neurovascular injury in ischemic stroke [J]. Circ Res，2017，120（3）：449-471.
[2] Chamorro á，Dirnagl U，Urra X，et al. Neuroprotection in acute stroke：targeting excitotoxicity，oxidative and nitrosative stress，and inflammation [J]. Lancet Neurol，2016，15（8）：869-881.
[3] Hashem SS，Helmy SM，El-Fayomy NM，et al. Predictors of stroke outcome：the role of hemorheology，natural anticoagulants，and serum albumin [J]. Egypt J Neurol Psychiatr Neurosurg，2018，54（1）：18.
[4] Marcinkowska-Gapińska A，Kowal P. Hemorheological studies of chosen clinical cases [J]. J Med Sci，2016，84（3）：197-200.
[5] 高维，王嘉麟，邢佳，等.浅谈从气血论治缺血性脑卒中[J].辽宁中医杂志，2017，44（8）：1770-1773.
[6] 高长玉，吴成翰，赵建国，等.中国脑梗死中西医结合诊治指南（2017）[J].中国中西医结合杂志，2018，38（2）：136-144.
[7] 李园，谢雁鸣，霍剑，等.基于HIS数据库分析注射用丹参多酚酸盐对冠心病“凝血”和“血小板”指标的影响[J].时珍国医国药，2016，27（1）：243-246.
[8] 中医学会神经病学分会脑血管病学组急性缺血脑卒中诊治指南撰学组.中国急性缺血性脑卒中诊治指南2010[J].中华神经科杂志，2010，2（4）：50-59.
[9] 胡晓，瞿浩，李世容，等.静脉溶栓联合亚低温治疗对急性脑梗死患者疗效及可能作用机制的研究[J].中国神经精神疾病杂志，2016，42（1）：15-21.
[10] Song SH，Kim JH，Lee JH，et al. Elevated blood viscosity is associated with cerebral small vessel disease in patients with acute ischemic stroke [J]. Bmc Neurol，2017， 17（1）：20.
[11] Dieplinger B，Bocksrucker C，Egger M，et al. Prognostic value of inflammatory and cardiovascular biomarkers for prediction of 90-day all-cause mortality after acute ischemic strokeresults from the Linz Stroke Unit Study [J]. Clin Chem，2017，63（6）：1101-1109.
[12] 刘玥，闫盈盈，翟所迪.注射用丹参多酚酸盐治疗心绞痛的系统评价再评价[J].中国临床药理学杂志，2016， 32（6）：560-562.
[13] 展翔，李坤彬，王东伟.丹参多酚酸盐联合灯盏生脉胶囊对缺血性脑卒中神经功能缺损程度及血液流变学的影响[J].广东医学，2017，38（16）：2555-2557.
[14] 房阁.注射用丹参多酚酸治疗缺血性脑卒中的临床效果分析[J].中西医结合心脑血管病杂志，2017，15（6）：725-727.
[15] 王创畅，吴伟，魏伟超，等.清热，活血中药调控TLR4/MyD88/NF-κB信号干预动脉粥样硬化大鼠模型的实验研究[J].中华中医药学刊，2018，36（3）：576-580.
[16] Zhang W，Zhu B，Cao W，et al. Research on the mechanism of drug-drug interaction between salvianolate injection and aspirin based on the metabolic enzyme and PK-PD model：study protocol for a PK-PD trial [J]. Trials，2018，19（1）：491.
[17] 梁芳，王翔云，曲华，等.丹参多酚酸盐联合用药治疗冠心病不稳定性心绞痛的系统评价[J].中医药导报，2018， 309（11）：108-112.
[18] 白蓉，王淑.注射用丹参多酚酸对脑缺血大鼠VEGF，IL-10的影响[J].中风与神经疾病杂志，2016，33（5）：411-416.
[19] 洪序溪.丹参多酚酸盐联合曲美他嗪治疗冠心病心绞痛的效果及安全性[J].中外医学研究，2017，15（35）：25-26.
[20] 薛梅苓，冯琴琴.丹参多酚酸盐治疗心血瘀阻型冠心病心绞痛临床疗效及安全性研究[J].中国药业，2016，25（18）：31-34.
[21] Liu L，Li J，Zhang Y，et al. Salvianolic acid B inhibits platelets as a P2Y12 antagonist and PDE inhibitor：evidence from clinic to laboratory [J]. Thromb Res，2014， 134（4）：866-876.
[22] Ma C，Yao Y，Yue QX，et al. Differential proteomic analysis of platelets suggested possible signal cascades network in platelets treated with salvianolic acid B [J]. PLoS One，2011，6（2）：e14692.
[23] Huang ZS，Zeng CL，Zhu LJ，et al. Salvianolic acid A inhibits platelet activation and arterial thrombosis via inhibition of phosphoinositide 3-kinase [J]. J Thromb Haemost，2010，8（6）：1383-1393.