Prevalence rate of mild cognitive impairment among the elderly in a suburban area of Shanghai City and analysis on its influencing factors
HUANG Wuquan1,2 LU Yuan3 YU Dehua3
1.Department of General Practice, School of Medicine, Tongji University, Shanghai 200092, China;
2.Community Health Service Center of Jiading Town in Jiading District, Shanghai 201800, China;
3.Department of General Practice, Yangpu Hospital, Tongji University, Shanghai 200082, China
Abstract：Objective To understand the prevalence rate of mild cognitive impairment (MCI) among the elderly in a suburban area of Shanghai City, and to explore the risk factors of MCI in the elderly, so as to provide scientific basis for the prevention and treatment of MCI in the elderly. Methods Using cluster sampling method, 705 elderly people over 65 years old in Jiading Town Street of Jiading District in Shanghai were selected from July to December 2018 for general health status questionnaire survey and Montreal cognitive assessment-basic (MoCA-B) test. Results Seven hundred and three valid questionnaires were obtained. The MoCA-B score of the elderly in community was 24(21,26) points. The prevalence rate was 19.1%. Univariate analysis showed that compared with the MCI group, the age of the non-MCI group was lower (P ＜ 0.05); the prevalence rate of MCI among the elderly in community with different educational levels, number of children born, living conditions, economic satisfaction degrees, activity status and whether they had diabetes mellitus, coronary heart disease and stroke had significant differences (P ＜ 0.05), and there was no significant difference in the prevalence rate of MCI between hypertensive patients and non-hypertensive patients (P ＞ 0.05). Multivariate unconditional Logistic regression analysis showed that advanced age (OR = 1.047, 95%CI: 1.010-1.084), three or more children born (OR = 1.876, 95%CI: 1.004-3.503), and diabetes mellitus (OR = 2.003, 95%CI: 1.338-2.997) were risk factors for MCI; living with children (OR = 0.305, 95%CI: 0.095-0.980) and above moderate exercise (OR = 0.260, 95%CI: 0.089-0.761) were protective factors for MCI. Conclusion With the increase of age, the average score of MoCA-B scale of the elderly decreases significantly. MCI intervention should be carried out as soon as possible for the elderly, who are not active and doesn′t live with their children, in order to prevent and delay the occurrence of Alzheimer′s disease.
黄武全1,2 陆媛3 于德华3. 上海市某近郊城区老年人轻度认知障碍患病率及其影响因素分析[J]. 中国医药导报, 2019, 16(21): 59-63,68.
HUANG Wuquan1,2 LU Yuan3 YU Dehua3. Prevalence rate of mild cognitive impairment among the elderly in a suburban area of Shanghai City and analysis on its influencing factors. 中国医药导报, 2019, 16(21): 59-63,68.
[1] Dubois B，Feldman HH，Jacova C，et al. Research criteria for the diagnosis of Alzheimer′s disease：Revising the NINCDS-ADRDA criteria [J]. Lancet Neurol，2007，6（8）：734-746.
[2] Ebly EM，Hogan DB，Parhad IM. Cognitive impairment in the nondemented elderly. Results from the Canadian Study of Health and Aging [J]. Arch Neurol，1995，52（6）：612-619.
[3] Ritchie K，Artero S，Touchon J. Classification criteria for mild cognitive impairment：a population-based validation study [J]. Neurology，2001，56（1）：37-42.
[4] Luis CA，Loewenstein DA，Acevedo A，et al. Mild cognitive impairment：directions for future research [J]. Neurology，2003，61（4）：438-444.
[5] Morrison JH，Hof PR. Life and death of neurons in the aging brain [J]. Science，1997，278（5337）：412-419.
[6] Busse A，Hensel A，Guhne U，et al. Mild cognitive impairment：long-term course of four clinical subtypes [J]. Neurology，2006，67（12）：2176-2185.
[7] Roberts RO，Geda YE，Knopman DS，et al. The Mayo Clinic Study of Aging：design and sampling，participation，baseline measure and sample characteristics [J]. Neuroepidemiology，2008，30（1）：58-69.
[8] Fischer P，Jungwirth S，Zehetmayer S，et al. Conversion from subtypes of mild cognitive impairment to Alzheimer dementia [J]. Neurology，2007，68（4）：288-291.
[9] 高橋若生，刘芳，陈谅.轻度认知功能障碍[J].日本医学介绍，2005，26（3）：117-119.
[10] 顾辨辨，严光，周树生.合肥地区轻度认知功能障碍的流行病学调查及叶酸的干预效果[J].中国临床保健杂志，2014，17（5）：475-477.
[11] Ding D，Zhao Q，Guo Q，et al. Prevalence of mild cognitive impairment in an urban community in China：a cross-sectional analysis of the Shanghai Aging Study [J]. Alzheimers Dement，2015，11（3）：300-309. doi：10.1016/j.jalz.2013.11.002.
[12] Rao D，Luo X，Tang M，et al. Prevalence of mild cognitive impairment and its subtypes in community-dwelling residents aged 65 years or older in Guangzhou，China [J]. Arch Gerontol Geriatr，2018，75：70-75. doi：10.1016/j.archger.2017.11.003.
[13] Jia J，Zhou A，Wei C，et al. The prevalence of mild cognitive impairment and its etiological subtypes in elderly Chinese [J]. Alzheimers Dement，2014，10（4）：439-447. doi： 10.1016/j.jalz.2013.09.008.
[14] 拓西平.老年人认知功能障碍研究进展[J].中华老年多器官疾病杂志，2014，13（5）：321-326.
[15] Chen KL，Xu Y，Chu AQ，et al. Validation of the Chinese Version of Montreal Cognitive Assessment Basic for Screening Mild Cognitive Impairment [J]. J Am Geriatr Soc，2016，64（12）：e285-e290.
[16] 叶国英，陈健尔，陈芙蓉，等.老年痴呆患病率状况调查及相关因素分析研究[J].中国农村卫生事业管理，2011， 31（2）：152-155.
[17] 杨凤姣，李艳，曹仲珍.社区老年人轻度认知障碍的调查分析[J].护理实践与研究，2010，7（17）：123-125.
[18] 江海，张建安，王粉春，等.太仓市农村老年人轻度认知功能障碍流行病学调查与分析.[J].中国慢性病预防与控制，2013，21（2）：178-181.
[19] 常小红，刘胜鲲.老年人认知功能障碍影响因素研究进展[J].中国现代医生，2016，54（19）：161-164.
[20] 范德康，李琼爱，施俊霞.健康体检老年人轻度认知功能障碍的患病率调查[J].中国临床保健杂志，2017，20（2）：195-196.
[21] 刘梦姣，曾慧.2型糖尿病并发轻度认知功能障碍危险因素研究进展[J].中国老年学杂志，2015，35（13）：3776-3779.
[22] Roberts RO，Knopman DS，Geda YE，et al. Association of diabetes with amnestic and nonamnestic mild cognitive impairment [J] Alzheimers Dement，2014，10（1）：18-26. doi：10.1016/j.jalz.2013.01.001.
[23] 沈银.广州地区城乡65 岁及以上老人轻度认知障碍和痴呆的流行病学调查[D].广州：广州医学院，2011.
[24] Devi Mohan，Thomas Iype，Sara Varghese，et al. A cross-sectional study to assess prevalence and factors associated with mild cognitive impairment among older adults in an urban area of Kerala，South India[J].BMJ Open，2019，9（3）：e025473. doi：10.1136/bmjopen-2018-025473.
[25] Groot C，Hooghiemstra AM，Raijmakers PG，et al. The effect of physical activity on cognitive function in patients with dementia：a meta-analysis of randomized control trials [J]. Ageing Res Rev，2016，25：13-23. doi：10.1016/j.arr.2015.11.005
[26] 严飞，陈阳，杨蓉，等.轻度认知障碍的社区干预措施进展研究[J].中国全科医学，2018，21（12）：1402-1407.
2019, Vol. 16 
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