巨噬细胞自噬在炎症性疾病中的作用研究进展

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摘要巨噬细胞是机体重要的固有免疫细胞之一，参与免疫防御和炎症调节。自噬能够调控巨噬细胞的吞噬、抗原呈递功能，还可通过调控巨噬细胞的极化方向来调节巨噬细胞在炎症发生发展和消退中的作用。巨噬细胞自噬参与了脓毒症、急性肺损伤、炎症性肝损伤、动脉粥样硬化、类风湿关节炎等许多炎症性疾病的发生发展或消退过程。本文综述了巨噬细胞自噬在炎症性疾病中的作用研究进展，并对其作为潜在治疗靶点进行了分析。

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	成梦群尹健彬张旋

关键词 ：巨噬细胞, 自噬, 炎症性疾病, 免疫

Abstract：Macrophages are one of the important innate immune cells in the body, which are involved in immune defense and regulation of inflammation. Autophagy can regulate the phagocytosis and antigen presenting function of macrophages. It can also regulate the role of macrophages in the occurrence, development and regression of inflammation by regulating the polarization direction of macrophages. Macrophage autophagy is involved in the occurrence, development and regression of many inflammatory diseases, such as sepsis, acute lung injury, inflammatory liver injury, atherosclerosis, rheumatoid arthritis and so on. This article reviews the research progress of macrophage autophagy in inflammatory diseases, and analyzes the possibility of macrophage autophagy as a potential target for treatment of inflammatory diseases.

Key words： Macrophage Autophagy Inflammatory diseases Immunity

基金资助:国家自然科学基金资助项目（81460565）；
云南省中青年学术技术带头人后备人才培养项目（2015HB042）。

通讯作者: 张旋(1979.9-)，男，博士，副教授，硕士生导师；研究方向：抗炎与免疫药理。

作者简介: 成梦群(1990.8-)，女，昆明医科大学2016级药理学专业在读硕士研究生；研究方向：抗炎与免疫药理。

引用本文:

成梦群尹健彬张旋. 巨噬细胞自噬在炎症性疾病中的作用研究进展[J]. 中国医药导报, 2019, 16(21): 35-38.
CHENG Mengqun YIN Jianbin ZHANG Xuan. Research progress on the role of macrophage autophagy in inflammatory diseases. 中国医药导报, 2019, 16(21): 35-38.

链接本文:

http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2019/V16/I21/35

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