Abstract:Objective To study the expression and clinical significance of urothelial carcinoma antigen 1 (UCA1) and micoRNA-141 (miR-141) in bladder cancer tissue. Methods A total of 83 patients with bladder cancer admitted to Linyi Cancer Hospital from February 2013 to February 2015 were taken as research objects. The expression of UCA1 and miR-141 were detectd by real-time fluorescent quantitative polymerase chain reaction and the relationship between the expression of UCA1 and miR-141 and the clinicopathological characteristics of the patients was analyzed. In addition, all patients were followed up for 3 years and divided into survival group (n = 39) and death group (n = 44) according to different survival conditions. The expression of UCA1 and miR-141 was compared between the two groups. Results The positive rate of UCA1 and miR-141 in bladder cancer tissues was higher than those in adjacent normal tissues (all P < 0.05). The positive rate of UCA1 in bladder cancer with pathological grade G1, clinical stage T1-T2 and no lymph node metastasis was lower than that in bladder cancer with pathological grade G2-G3, clinical stage T3-T4 and lymph node metastasis (all P < 0.05). The positive rate of miR-141 in bladder cancer tissues with clinical stage T1-T2 and no lymph node metastasis was lower than that in bladder cancer tissues with clinical stage T3-T4 and lymph node metastasis (all P < 0.05). The positive rate of UCA1 and miR-141 in survival group was lower than those in death group (all P < 0.05). Conclusion UCA1 and miR-141 is highly expressed in bladder cancer tissues. The two indicators mentioned above can be used in clinical work to evaluate the condition and prognosis of patients with bladder cancer.