Effect of Dexamethasone intrauterine perfusion on E2R, TGF- beta 1 and VEGF in endometrium with moderate and severe intrauterine adhesion
WEI Shu1 YAO Hong2 ZHANG Yucui1
1.Department of Gynecology, Nanshan District People′s Hospital of Shenzhen City, Guangdong Province, Shenzhen 518052, China;
2.Department of Gynecology, Nanshan District Shekou People′s Hospital of Shenzhen City, Guangdong Province, Shenzhen 518055, China
Abstract:Objective To investigate the effect of intrauterine perfusion of Dexamethasone on the estradiol receptor (E2R), transfotruing growth factor-beta 1 (TGF-β1), vescular endothelial growth factor (VEGF) of endometrium with moderate and severe intrauterine adhesion. Methods From October 2016 to June 2017, 120 patients with moderate and severe intrauterine adhesion in Nanshan District People′s Hospital of Shenzhen City, Guangdong Province were selected as the research objects, and they were divided into research group and control group by the random number group, with 60 cases in each group. The research group were given Dexamethasone 5 mg + normal saline 10 mL of perfusion palace 10 min; and the control group was perfused with the same amount of normal saline. The level changes of E2R, TGF-β1 and VEGF before and after artificial treatment were observed. Results There were statistically significant differences in the total effective treatment for 1 and 3 months after artificial treatment between the two groups (P < 0.05); the total effective rate of research group 3 months after artificial treatment was higher than that 1 month after artificial treatment, the difference was statistically significant (P < 0.05). The E2R, TGF-β1 and VEGF of the two groups 1 and 3 months of after artificial treatment were all lower than those before treatment of the same group, and those 3 months after artificial treatment were lower than 1 month after artificial treatment, the differences were statistically significant (P < 0.05). The E2R, TGF-β1 and VEGF of the research group 1 and 3 months after artificial treatment were all lower than those of the control group, the differences were statistically significant (P < 0.05). Conclusion Dexamethasone can alter the expression of E2R, TGF-β1 and VEGF in endometrium samples, and can assist in the post-hysteroscopic treatment of patients with moderate and severe intrauterine adhesion by intrauterine perfusion.
魏舒1 姚红2 张玉翠1. 宫腔灌注地塞米松对中重度宫腔粘连子宫内膜E2R、TGF-■1、VEGF的影响[J]. 中国医药导报, 2019, 16(20): 108-111.
WEI Shu1 YAO Hong2 ZHANG Yucui1. Effect of Dexamethasone intrauterine perfusion on E2R, TGF- beta 1 and VEGF in endometrium with moderate and severe intrauterine adhesion. 中国医药导报, 2019, 16(20): 108-111.