microRNA-21在食管癌中的研究进展

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摘要食管癌是我国常见的消化系统恶性肿瘤之一。食管癌具体发病机制尚不清楚。 microRNA是一类内源性非编码蛋白短链RNA，参与调控细胞增殖、分化、凋亡、耐药和侵袭转移等多种生物学行为。其中miR-21最受关注。miR-21在食管癌细胞或组织中高表达，发挥着类似于癌基因的作用。miR-21通过对靶基因的调控，参与食管癌细胞增殖、凋亡、侵袭、耐药和转移等过程。通过抑制miR-21的表达或阻碍miR-21与靶基因的相互作用在食管癌治疗中具有良好的应用前景。本文就miR-21在食管癌中的研究进展进行综述。

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	杨鲸蓉1 吴波2▲

关键词 ： microRNA-21, 食管癌, 生物学行为, 预后

Abstract：Esophageal cancer is one of the most common digestive system neoplasms in China. The mechanism of esophageal cancer is still unclear. microRNA is a kind of endogenous non-coding short RNA, which regulates many tumor biological behaviors,such as cell multiplication, differentiation, apoptosis, drug resistance and invasion. miR-21 is valued highly in miRNA. It express highly in esophageal cancer cell and tissue. miR-21 participates in esophageal cancer cell multiplication, differentiation, apoptosis, drug resistance and metastasis via regulating gene expression. This review summarizes the advances in research on miR-21 in esophageal cancer .

Key words： MicroRNA-21 Esophageal cancer Biological behaviors Prognosis

基金资助:福建省自然科学基金资助项目（2017J01320）。

通讯作者: ▲通讯作者

引用本文:

杨鲸蓉1 吴波2▲. microRNA-21在食管癌中的研究进展[J]. 中国医药导报, 2017, 14(16): 40-43.
YANG Jingrong1 WU Bo2▲. Advances research of microRNA-21 in esophageal cancer. 中国医药导报, 2017, 14(16): 40-43.

链接本文:

http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2017/V14/I16/40

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