Abstract：Objective To study the inhibition of anthropogenic colon cancer cells activity constituents of Pteris dispar. Methods The medicinal materials were extracted by 95% ETOH. Compounds were obtained by kinds of chromatographies including polyamide, Sephadex LH-20 and pre-HPLC and the structures identified by NMR. In vitro antitumor activity was tested by SRB methods. Results 5 compounds were obtained from the plant and their structures were established as geopyxin A (1), geopyxin C (2), ent-11β-acetoxykaur-16-en-18-ol (3), 7β, 16α, 17-trihydroxy-ent-kauran-19-oic acid (4) and neolaxiflorin K (5). Compounds 1, 2 and 5 showed strong in vitro antitumor activity against HCT-116, with IC50 values of 1.20, 2.45 and 3.26 μmol/L respectively. Conclusion Compounds 1-5 are obtained from Pteris dispar for the first time.
孙丹 张艳 孙强 彭玉勃 王磊. 民族药刺齿凤尾蕨抑制人源结肠癌细胞活性成分研究[J]. 中国医药导报, 2017, 14(16): 20-23.
SUN Dan ZHANG Yan SUN Qiang PENG Yubo WANG Lei. Study on chemical constituents and their inhibition of anthropogenic colon cancer cells bioactivity from ethnic medicine Pteris dispar. 中国医药导报, 2017, 14(16): 20-23.
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