Research progress of microRNA in prevention and treatment of femoral head necrosis
YU Changsui1 ZHANG Xiaofeng2 XU Xilin2 YU Zhongbao3 WANG Shuren4 WANG Zhengchun1 PENG Yufei4 CHEN Weiheng5
1.School of Graduates, Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China;
2.The Third Department of Orthopedics, the Second Hospital Affiliated to Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150001, China;
3.Yu Zhongbao Chinese Medicine Clinic of Kuandian Manchu Autonomous County, Liaoning Province, Kuandian 118200, China;
4.The Second Department of Orthopedics, the First Hospital Affiliated to Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China;
5.The Third Department of Orthopedics, Wangjing Hospital of China Academy of Chinese Medical Science, Beijing 100102, China
Abstract：microRNAs (miRNAs) belongs to a small RNA of non-protein coding families, and is involved in many physiological and pathological processes. They are about 22 nucleotides long and have specific expression in human tissues or cells. One group of miRNAs has been shown to play a fundamental role in gene regulation in various kinds of orthopedics diseases, such as bone tumors, osteoarthritis, and rheumatoid arthritis. The study of miRNA in osteonecrosis of the femoral head can help to understand the pathogenesis of the disease more clearly. The main cause of osteonecrosis of the femoral head is the destruction of femoral head blood supply, and the main symptoms are bone and muscle dysfunction. The recent studies show that microRNA plays an important role in the regulation of microcirculation of osteonecrosis of the femeral head, local microcirculation dysfunction caused by other diseases and bone cells apoptosis. In this paper, the related research results of microRNA and osteonecrosis of the femoral head in recent years are analyzed and summarized, and the prospect of microRNA in the prevention and treatment of osteonecrosis of the femoral head is also looked forward.
[1] Boucherat O，Potus F，Bonnet S. microRNA and pulmonary hypertension [J]. Adv Exp Med Biol，2015，888：237-252.
[2] Drusco A，Nuovo GJ ，Zanesi N，et al. MicroRNA profiles discriminate among colon cancer metastasis [J]. PLoS One，2014，9（6）：e96670.
[3] Mont MA，Jones LC，Hungerford DS. Nontraumatic osteonecrosis of the femoral head：ten years later [J]. Bone Joint Surg，2006，88（5）：1117-1132.
[4] Kerachian MA，Séguin C，Harvey EJ. Glucocorticoids in osteonecrosis of the femoral head：a new understanding of the mechanisms of action [J]. Steroid Biochem Mol Biol，2009，114（4）：121-128.
[5] Roy S，Benz F，Luedde T，et al. The role of miRNAs in the regulation of infammatory processes during hepatofbrogenesis [J]. Hepatobiliary Surg Nutr，2015，4（1）：24-33.
[6] Chung AC，Lan HY. microRNAs in renal fbrosis [J]. Front Physiol，2015，6（2）：50.
[7] Lee RC，Feinbaum RL，Ambros V. The C. elegans Heterochronic Gene lin-4 Encodes Small RNAs with Antisense Complementarity to & II-14 [J].Cell，1993，75（5）：843-854.
[8] Lawrie CH，Gal S，Dunlop HM，et al. Pushkaran B. Detection of elevated levels of tumor-associated microRNAs in serum of patients with diffuse large B cell lymphoma [J]. Br J Haematol，2008，141（5）：672-675.
[9] Wang X，Qian W，Wu Z，et al. Preliminary screening of differentially expressed circulating microRNAs in patients with steroid-induced osteonecrosis of the femoral head [J]. Mol Med Rep，2014，10（6）：3118-3124.
[10] Sethi S，Ali S，Sethi S，et al. MicroRNAs in personalized cancer therapy [J]. Clin Genet，2014，86（1）：68-73.
[11] Xia L，Zhang D，Du R，et al. miR-15b and miR?16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells [J]. Int J Cancer，2008，123（2）：372-379.
[12] Zhou Q，Chen F，Fei Z，et al. Genetic variants of lncRNA HOTAIR contribute to the risk of osteosarcoma [J]. Oncotarget，2016，7（15）：19928-19934.
[13] Ha M，Kim VN. Regulation of microRNA biogenesis [J]. Nat Rev Mol Cell Biol，2014，15（8）：509-524.
[14] Van der Jagt D，Mokete L，Pietrzak J，et al. Osteonecrosis of the femoral head：evaluation and treatment [J]. J Am Acad Orthop Surg，2015，23（2）：69-70.
[15] Johnson AJ，Mont MA，Tsao AK，et al. Treatment of femoral head osteonecrosis in the United States：16-year analysis of the Nationwide Inpatient Sample [J]. Clin Orthop Relat Res，2014，472（2）：617-623.
[16] Kafchinski LA，Jones KB. MicroRNAs in osteosarcomagenesis [J]. Adv Exp Med Biol，2014，804：119-127.
[17] Hudson MB，Woodworth-Hobbs ME，Zheng B，et al. miR-23a is decreased during muscle atrophy by a mechanism that includes calcineurin signaling and exosome-mediated export [J]. Am J Physiol Cell Physiol，2014，306（6）：C551-558.
[18] Liu G，Luo G，Bo Z，et al. Impaired osteogenic differentiation associated with connexin43/microRNA-206 in steroid-induced avascular necrosis of the femoral head [J]. Exp Mol Pathol，2016，101（1）：89-99.
[19] Arioka M，Takahashi-Yanaga F，Sasaki M，et al. Acceleration of bone regeneration by local application of lithium：Wnt signal-mediated osteoblastogenesis and Wnt signal-independent suppression of osteoclastogenesis [J]. Biochem Pharmacol，2014，90（4）：397–405.
[20] Gulyaeva LF，Kushlinskiy NE. Regulatory mechanisms of microRNA expression [J]. J Translat Med，2016，14（1）：143.
[21] Papadimitriou N，Thorfve A，Brantsing C，et al. Cell viability and chondrogenic differentiation capability of human mesenchymal stem cells after iron labeling with iron sucrose [J]. Stem Cells Dev，2014，23（21）：2568-2580.
[22] Seeliger C，Karpinski K，Haug AT，et al. Five freely circulating miRNAs and bone tissue miRNAs are associated with osteoporotic fractures [J]. J Bone Miner Res，2014， 29（8）：1718-1728.
[23] Hwang S，Park SK，Lee HY，et al. miR-140-5p suppresses BMP2-mediated osteogenesis in undifferentiated human mesenchymal stem cells [J]. FEBS Lett，2014，588（17）：2957-2963.
[24] Karlsen TA，Jakobsen RB，Mikkelsen TS，et al. microRNA-140 targets RALA and regulates chondrogenic differentiation of human mesenchymal stem cells by translational enhancement of SOX9 and ACAN [J]. Stem Cells Dev，2014，23（3）：290-304.
[25] Hill CR，Yuasa M，Schoenecker J，et al. Jagged1 is essential for osteoblast development during maxillary ossification [J]. Bone，2014，62（5）：10-21.
[26] Siculella L，Tocci R，Rochira A，et al. Lipid accumulation stimulates the cap-independent translation of SREBP-1a mRNA by promoting hnRNP A1 binding to its 5’-UTR in a cellular model of hepatic steatosis [J]. Biochim Biophys Acta，2016，1861（5）：471-481.
[27] Lin Y，Weisdorf DJ，Solovey A，et al. Origins of circulating endothelial cells and endothelial outgrowth from blood [J]. J Clin Invest，2000，105（1）：71-77.
[28] Huber BC，Grabmaier U，Brunner S. Impact of parathyroid hormone on bone marrow-derived stem cell mobilization and migration [J]. World J Stem Cells，2014，6（5）：637-643.
[29] Morrison SJ，Scadden DT. The bone marrow niche for haematopoietic stem cells [J]. Nature，2014，505（7483）：327-334.
[30] Rose JA，Erzurum S，Asosingh K. Biology and flow cytometry of proangiogenic hematopoietic progenitors cells [J]. Cytometry A，2015，87（1）：5-19.
[31] Martin EC，Qureshi AT，Dasa V，et al. MicroRNA regulation of stem cell differentiation and diseases of the bone and adipose tissue：Perspectives on miRNA biogenesis and cellular transcriptome [J]. Biochimie，2016，124：98-111.
2017, Vol. 14 
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