Abstract：Sestrin2 is a highly conserved, stress-inducible protein. As a important protein for P53-regulated mammalian target of rapamyein complex (mTORC1) signaling pathway, Sestrin2 activates AMP activated protein kinase (AMPK) and target it to phosphorylate tuberous seleresis complex (TSC2), thereby inhibiting mTORC1, reducing the ischemia-reperfusion injury. In recent years, there are great progress in the studis of Sestrin2. This paper reviews the role of Sestrin2 in anti-oxidative stress and the potential clinical application as a therapeutic target to prevent/treat related diseases.
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2017, Vol. 14 
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