Abstract：The treatment of bone defects is still a major challenge for orthopedics. Large bone defect repair can be accomplished using certain implant materials. The development of new degradable bone regeneration materials, the modification of existing bone repair materials and the application of new preparation processes are the development trends in the field of bone repair materials research. Among the biodegradable non-metallic synthetic materials, bioceramics are the most widely used biodegradable bone repair materials because of their similar composition and relatively high strength. Bioglass can form a tight connection with body tissue and can be used for surface treatment of orthopedic implants to improve implant compatibility. Biopolymers have high biological activity and loose structure, and have great application value in tissue engineering. The formulation of strategies for the application of this kind of materials should include comprehensive plans of materials science, biology science, clinical medicine and other disciplines. The technical means include the development of new formulations, doping of additives, application of new preparation techniques, etc. This article will review the advantages, disadvantages, development and preparation of these types of biodegradable synthetic bone tissue recycled materials.
[1] Sanzana ES，Navarro M，Ginebra MP，et al. Role of porosity and pore architecture in the in vivo bone regeneration capacity of biodegradable glass scaffolds [J]. J Biomed Mater Res A，2014，102（6）：1767-1773.
[2] Draenert M，Draenert A，Draenert K. Osseointegration of hydroxyapatite and remodeling-resorption of tricalcium-phosphate ceramics [J]. Microsc Res Techniq，2013，76（4）：370-380.
[3] Lu L，Zhang Q，Wootton DM，et al. Mechanical study of polycaprolactone-hydroxyapatite porous scaffolds created by porogen-based solid freeform fabrication method [J]. J Appl Biomater Func，2014，12（3）：145-154.
[4] Pati F，Song TH，Rijal G，et al. Ornamenting 3D printed scaffolds with cell-laid extracellular matrix for bone tissue regeneration [J]. Biomaterials，2015，37：230-241.
[5] Li HC，Wang DG，Chen CZ，et al. Preparation and characterization of laser cladding wollastonite derived bioceramic coating on titanium alloy [J]. Biointerphases，2015，10（3）：031007.
[6] Zhu H，Guo D，Qi W，et al. Development of Sr-incorporated biphasic calcium phosphate bone cement [J]. Biomed Mater，2017，12（1）：015016.
[7] Hu D，Li K，Xie Y，et al. Different response of osteoblastic cells to Mg2+，Zn2+ and Sr2+ doped calcium silicate coatings [J]. J Mater Sci-Mater M，2016，27（3）：56.
[8] Faruq O，Kim B，Padalhin AR，et al. A hybrid composite system of biphasic calcium phosphate granules loaded with hyaluronic acid-gelatin hydrogel for bone regeneration [J]. J Biomater Appl，2017，32（4）：433-445.
[9] Liu C，Zhai H，Zhang Z，et al. Cells Recognize and Prefer Bone-like Hydroxyapatite：Biochemical Understanding of Ultrathin Mineral Platelets in Bone [J]. Acs Appl Mater Inter，2016，8（44）：29 997-30 004.
[10] Prakasam M，Locs J，Salma-Ancane K，et al. Fabrication，Properties and Applications of Dense Hydroxyapatite：A Review [J]. J Func Biomater，2015，6（4）：1099-1140.
[11] Nabiyouni M，Bruckner T，Zhou H，et al. Magnesium-based bioceramics in orthopedic applications [J]. Acta Biomater，2018，66：23-43.
[12] Kim JA，Yun HS，Choi YA，et al. Magnesium phosphate ceramics incorporating a novel indene compound promote osteoblast differentiation in vitro and bone regeneration in vivo [J]. Biomaterials，2018，157：51-61.
[13] Mestres G，Ginebra MP. Novel magnesium phosphate cements with high early strength and antibacterial properties [J]. Acta Biomater，2011，7（4）：1853-1861.
[14] Meininger S，Mandal S，Kumar A，et al. Strength reliability and in vitro degradation of three-dimensional powder printed strontium-substituted magnesium phosphate scaffolds [J]. Acta Biomater，2016，31：401-411.
[15] Kazemi A，Abdellahi M，Khajeh-Sharafabadi A，et al. Study of in vitro bioactivity and mechanical properties of diopside nano-bioceramic synthesized by a facile method using eggshell as raw material [J]. Mater Sci Eng C Mater Biol Appl，2017，71：604-610.
[16] Ren Y，Sikder P，Lin B，et al. Microwave assisted coating of bioactive amorphous magnesium phosphate （AMP） on polyetheretherketone （PEEK） [J]. Mater Sci Eng C Mater Biol Appl，2018，85：107-113.
[17] Peitl O，Zanotto ED，Serbena FC，et al. Compositional and microstructural design of highly bioactive P2O5-Na2O-CaO-SiO2 glass-ceramics [J]. Acta Biomater，2012，8（1）：321-332.
[18] Jones JR. Reprint of：Review of bioactive glass：From Hench to hybrids [J]. Acta Biomater，2015，23 Suppl：S53-S82.
[19] Stevensson B，Yu Y，Eden M. Structure-composition trends in multicomponent borosilicate-based glasses deduced from molecular dynamics simulations with improved B-O and P-O force fields [J]. Phys Chem Chem Phys，2018， 20（12）：8192-8209.
[20] Nommeots-Nomm A，Labbaf S，Devlin A，et al. Highly degradable porous melt-derived bioactive glass foam scaffolds for bone regeneration [J]. Acta Biomater，2017， 57：449-461.
[21] Singh BN，Pramanik K. Development of novel silk fibroin/polyvinyl alcohol/sol-gel bioactive glass composite matrix by modified layer by layer electrospinning method for bone tissue construct generation [J]. Biofabrication，2017，9（1）：015028.
[22] Poh PSP，Hutmacher DW，Holzapfel BM，et al. In vitro and in vivo bone formation potential of surface calcium phosphate-coated polycaprolactone and polycaprolactone/bioactive glass composite scaffolds [J]. Acta Biomater，2016，30：319-333.
[23] Cattini A，Bellucci D，Sola A，et al. Microstructural design of functionally graded coatings composed of suspension plasma sprayed hydroxyapatite and bioactive glass [J]. J Biomed Mater Res B，2014，102（3）：551-560.
[24] Chen Q，Cabanas-Polo S，Goudouri OM，et al. Electrop-horetic co-deposition of polyvinyl alcohol （PVA） reinforced alginate-Bioglass（R） composite coating on stainless steel：mechanical properties and in-vitro bioactivity assessment [J]. Mater Sci Eng C Mater Biol Appl，2014， 40：55-64.
[25] Annabi N，Tamayol A，Uquillas JA，et al. 25th anniversary article：Rational design and applications of hydrogels in regenerative medicine [J]. Adv Mater，2014，26（1）：85-123.
[26] Kissling S，Seidenstuecher M，Pilz IH，et al. Sustained release of rhBMP-2 from microporous tricalciumphosphate using hydrogels as a carrier [J]. Bmc Biotechnol，2016，16（1）：44.
[27] Schiavi J，Reppel L，Charif N，et al. Mechanical stimulations on human bone marrow mesenchymal stem cells enhance cells differentiation in a three-dimensional layered scaffold [J]. J Tissue Eng Regen M，2018，12（2）：360-369.
[28] Ortega Z，Aleman ME，Donate R. Nanofibers and Microfibers for Osteochondral Tissue Engineering [J]. Adv Exp Med Biol，2018，1058：97-123.
[29] Kim BR，Nguyen TB，Min YK，et al. In vitro and in vivo studies of BMP-2-loaded PCL-gelatin-BCP electrospun scaffolds [J]. Tissue Eng A，2014，20（23/24）：3279-3289.
[30] Gamie Z，Macfarlane RJ，Tomkinson A，et al. Skeletal tissue engineering using mesenchymal or embryonic stem cells：clinical and experimental data [J]. Expert Opin Biol Th，2014，14（11）：1611-1639.
[31] Priddy LB，Chaudhuri O，Stevens HY，et al. Oxidized alginate hydrogels for bone morphogenetic protein-2 delivery in long bone defects [J]. Acta Biomater，2014，10（10）：4390-4399.
[32] Sithole MN，Kumar P，du Toit LC，et al. A 3D bioprinted in situ conjugated-co-fabricated scaffold for potential bone tissue engineering applications [J]. J Biomed Mater Res A，2018，106（5）：1311-1321.
2019, Vol. 16 
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