Changes of perioperative blood sedimentation and serum inflammatory cytokines concentrations in patients with femoral neck fracture and artificial femoral head replacement treatment and its clinical significance
WANG Chuangming ZHENG Xun CHEN Haibo ZENG Qingqiang
Department of Orthopedics, Traditional Chinese Medical Hospital of Shantou City, Guangdong Province, Shantou 515000, China
Abstract：Objective To study the changes of perioperative blood sedimentation and serum inflammatory cytokines concentrations in patients with femoral neck fracture and artificial femoral head replacement treatment and its clinical significance. Methods From May 2013 to May 2015, in Traditional Chinese Medical Hospital of Shantou City, 66 patients with femoral neck fracture and artificial femoral head replacement treatment were selected, they were given postoperative 1 year follow-up. Perioperative blood sedimentation and serum inflammatory cytokines concentrations of the were detected. Results Perioperative blood sedimentation and serum IL-6, TNF-α and PCT and other inflammatory markers levels in patients with infection were higher than that of patients without infection, the differences were statistically significant (P < 0.05). After 1 year follow-up, perioperative blood sedimentation and inflammatory markers levels in patients with Harris score ≥80 points were lower than that of patients with Harris score <80 points, the differences were statistically significant (P < 0.05). Perioperative blood sedimentation and serum IL-6, TNF-α and PCT levels in patients with femoral neck fracture and artificial femoral head replacement treatment were correlated with the infection incidence and Harris scores (P < 0.05). ROC curve analysis results showed that value of perioperative blood sedimentation and serum inflammatory factors levels in patient with femoral neck fracture and had artificial femoral head replacement treatment unitedly diagnosing the infection was high; and the value of perioperative blood sedimentation and serum inflammatory factors levels in patient with femoral neck fracture and had artificial femoral head replacement treatment unitedly predicting the hip function recovery was also good. Conclusion Perioperative blood sedimentation and serum inflammatory factors levels in patient with femoral neck fracture and had artificial femoral head replacement treatment are closely related to the infection and hip function, and it may help to evaluating the infection and the hip joint function recovery.
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2017, Vol. 14 
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