Research progress of effect of glucagon-like peptide-1 receptor agonists on vascular complications in patients with type 2 diabetes mellitus
LIU Jingjing1 WEI Li2 WANG Jianbo2
1.Department of Interventional Radiology, the Sixth People′s Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200023, China;
2.Department of Endocrinology, the Sixth People′s Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200023, China
Abstract：Type 2 diabetes is a major risk factor of atherosclerotic disease. Thus, the prevention and treatment of diabetic vascular lesions is another important purpose in addition to hypoglycemic for diabetes patients. Exogenous administration of glucagon-like peptide-1 (GLP-1) or GLP-1 receptor agonist is a new kind of antidiabetic drugs, its hypoglycemic effect has been very clear, mainly through the combination with GLP-1 receptors, thereby promoting insulin secretion to reduce blood glucose. In recent years, domestic and foreign studies have found that GLP-1 receptor agonists also have cardiovascular protection. The mechanism may be achieved by improving the function of vascular endothelial cells, antioxidant stress, lowering blood pressure, lowering blood lipid, inhibiting the apoptosis of myocardial cells and so on. However, whether GLP-1 receptor agonists can improve the development of vascular complications in patients with T2DM remains to be confirmed for a long time.
刘晶晶1 魏丽2 王建波2. GLP-1受体激动剂对2型糖尿病患者血管病变影响的研究进展[J]. 中国医药导报, 2017, 14(18): 38-41.
LIU Jingjing1 WEI Li2 WANG Jianbo2. Research progress of effect of glucagon-like peptide-1 receptor agonists on vascular complications in patients with type 2 diabetes mellitus. 中国医药导报, 2017, 14(18): 38-41.
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2017, Vol. 14 
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