Abstract:Objective To compare the effectiveness and safety of tube-sealing fluids of Sodium Heparin, Sodium Citrate and Urokinase for the tube-sealing of central venous catheters in patients with hemofiltration. Methods Sixty hemofiltration patients with central venous catheters admitted to Department of Critical Care Medicine, Beijing Friendship Hospital, Capital Medical University from May to October 2016 were selected, and they were divided into three groups by random table number, with 20 cases in each group. Group A was given Sodium Heparin to seal tube, group B was given Sodium Citrate to seal tube, group C was given Urokinase to seal tube. The effectiveness (including catheter jam, catheter dysfunction) and safety (including the incidence of gastrointestinal bleeding, drug allergy, catheter-related infection, hypocalcemia, errhysis around puncture point or subcutaneous hematoma) of the three groups after central vena catheterization for 21 d were compared. Results Among 60 patients, the incidence of catheter dysfunction (61.67%), errhysis around puncture point or subcutaneous hematoma (58.33%) was high and the incidence of drug allergy, catheter jam, catheter-related infection, gastrointestinal bleeding and hypocalcemia was low (<5.00%). There were statistically significant differences in the incidence of catheter dysfunction and errhysis around puncture point or subcutaneous hematoma among the three groups (P < 0.05). The incidence of catheter dysfunction in the group B and C was lower than that of group A, with statistically significant differences (P < 0.05). The incidence of errhysis around puncture point or subcutaneous hematoma in the group B was lower than those of group A and C, with statistically significant differences (P < 0.05). Conclusion The tube-sealing of Sodium Citrate in central venous catheters of patients with hemofiltration is more safe and effective, which is worthy of clinical popularization.
金艳鸿 尹璐. 三种封管液对血滤患者中心静脉导管封管效果的比较研究[J]. 中国医药导报, 2017, 14(28): 178-181.
JIN Yanhong YIN Lu. Comparative study on the effects of three tube-sealing fluids for the tube-sealing of central venous catheters in patients with hemofiltration. 中国医药导报, 2017, 14(28): 178-181.