Application of prolonged protocol in aged women undergoing IVF/ICSI treatment
LU Xiaosheng1 WU Yanhong1 XI Haitao1 SU Weijue2 ZHAO Junzhao1
1.Reproductive Center, the Second Affiliated Hospital of Wenzhou Medical University, Zhejiang Province, Wenzhou 325027, China;
2.the Second Clinical College of Wenzhou Medical University, Zhejiang Province, Wenzhou 325000,China
Abstract：Objective To assess the feasibility of prolonged protocol performed in aged patients undergoing in vitro fertilization/intracytoplasmic sperm injection（IVF/ICSI） treatment. Methods A Retrospective analysis was conducted on the data of 333 aged women who were given IVF/ICSI treatment with fresh embryo transplantation in the Reproductive Center of the Second Affiliated Hospital of Wenzhou Medical University from July 2016 to July 2018，of which 143 cases were given mild stimulation，and 190 cases were given prolonged protocol. The laboratory and clinical outcomes of two schemes were compared. Then patients in prolonged group were further divided into two groups according to their age. one included 107 cases aged >35-38 years old and the other contained 83 cases aged >38-42 years old，and laboratory and clinical outcomes were compared between the groups. Results Patients with the prolonged protocol used more doses of gonadotropin and longer treatment duration than those with mild stimulation, but patients with prolonged protocol achieved higher clinical pregnancy rates and embryo implantation rates. In patients with mild stimulation，the clinical pregnancy rate of patients aged >38-42 years old group was similar to that of the >35-38 year-old group（P > 0.05），while the embryo implantation rate was lower than the >35-38 year-old group （P < 0.05）. Conclusion The prolonged protocol is expected to be one of preferred option for elderly patients with tolerable ovarian reverse（≤ 42 years old, AFC≥5 and basic FSH≤12 U/L）.
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2019, Vol. 16 
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