Research progress of new target GDF15/GFRAL signaling pathways for the treatment of obesity and metabolic related diseases
XU Chuanyang1 WANG Zhaowei1 HE Lei1 PANG Zhijun1 ZHU Yichao2 LI Weina1 LI Zhengmin3▲
1.School of Pharmacy, the Fourth Military Medical University, Shaanxi Province, Xi′an 710032, China;
2.Brigade of Undergraduates, the Fourth Military Medical University, Shaanxi Province, Xi′an 710032, China;
3.Department of Anesthesiology, Tangdu Hospital, the Fourth Military Medical University, Shaanxi Province, Xi′an 710038, China
Abstract：Growth differentiation factor 15 (GDF15) is a member of the transforming growth factor β superfamily and is involved in various biological processes such as energy homeostasis, body weight regulation, and cachexia driven caused by cancer and chronic diseases. GDF15 is able to control food intake and energy metabolism, which makes it important in the treatment of disorders such as obesity and anorexia. Further research into the biological function of this molecule has been limited due to the lack of its defined receptors, signaling mechanisms and target tissues. The GDNF family α-like receptor (GFRAL) has recently been identified as a receptor for the GDF15 molecule and is responsible for mediating the biological effects of controlling energy intake and energy metabolism regulation. The discovery of the GDF15/GFRAL signaling pathway provides new insights into the treatment of obesity and metabolic related diseases. In this paper, the biological function of energy stabilization of GDF15 and the influence of the discovery of GFRAL receptor on this field are briefly summarized.
徐传洋1 王昭维1 何磊1 逄志骏1 朱一超2 李维娜1 李正民3▲. 肥胖及代谢相关疾病治疗新靶点GDF15/GFRAL信号通路的研究进展[J]. 中国医药导报, 2019, 16(18): 25-29.
XU Chuanyang1 WANG Zhaowei1 HE Lei1 PANG Zhijun1 ZHU Yichao2 LI Weina1 LI Zhengmin3▲. Research progress of new target GDF15/GFRAL signaling pathways for the treatment of obesity and metabolic related diseases. 中国医药导报, 2019, 16(18): 25-29.
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