Effects of acupuncture on cancer-related fatigue in breast cancer patients at the rehabilitation stage: a randomized controlled trial
YU Mingwei1 LI Daorui2 YANG Guowang1 XU Yongmei1 WANG Xiaomin1
1.Department of Oncology, Beijing Hospital of Traditional Chinese Medicine, Beijing 100010, China;
2.Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
Abstract：Objective To observe the effects of acupuncture on cancer-related fatigue in breast cancer patients at the rehabilitation stage. Methods 72 breast cancer patients at the rehabilitation stage who were suffering from at least moderate fatigue were recruited from Beijing Hospital of Traditional Chinese Medicine, Capital Medical University and Guang'anmen Hospital, China Academy of Chinese Medical Sciences from January 2013 to June 2014. They were randomly divided into intervention group and control group, each 36 cases. In the intervention group, participants received traditional Chinese acupuncture on Baihui (GV 20), Neiguan (PC 6), Qihai (CV 6), Zusanli (ST 36), Sanyinjiao (SP 6). Shallow acupunctures were applied in the control group. Treatment was given twice a week for 4 weeks, and follow-up was given for 4 weeks at the end of treatment. The primary index was cancer-related fatigue, which was evaluated by Piper fatigue scale, the secondary indexes were sleep, emotion, physical functioning, which were respectively evaluated by Pittsburgh sleep quality index (PSQI), hospital anxiety and depression scale (HADS), Eastern cooperative oncology group (ECOG) performance status. Adverse events and side effects were compared between two groups. Results No significant differences were found in general fatigue or in four dimensions between the two groups after treatment and during follow-up period (P ＞ 0.05). The general fatigue, feel dimension and cognitive/emotional dimension in the acupuncture group after treatment and during follow-up period had significant differences compared with those before treatment (P ＜ 0.01 or P ＜ 0.05). No significant differences were found in the scores of PSQI, HADS and ECOG scores between the two groups (P ＞ 0.05). After treatment, the depression scores in both groups were all lower than those before treatment, the differences were statistically significant (P ＜ 0.05). Conclusion Our study is underpowered to find a statistically significant difference in general fatigue in breast cancer patients at the rehabilitation stage. The improvement in feel dimension, cognitive/emotional dimension and depression scores may be associated with the placebo effects and the mechanisms that cancer-related fatigue is closely related to psychological factors.
于明薇1 李道睿2 杨国旺1 徐咏梅1 王笑民1. 针刺治疗康复期乳腺癌患者癌因性疲乏的随机对照研究[J]. 中国医药导报, 2017, 14(19): 89-93.
YU Mingwei1 LI Daorui2 YANG Guowang1 XU Yongmei1 WANG Xiaomin1. Effects of acupuncture on cancer-related fatigue in breast cancer patients at the rehabilitation stage: a randomized controlled trial. 中国医药导报, 2017, 14(19): 89-93.
2017, Vol. 14 
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