磁敏感加权成像测量脑铁沉积在帕金森病中的临床应用

摘要
图/表
参考文献(21)
相关文章 (1)

全文: PDF (767 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要目的通过磁敏感加权成像技术（SWI）定量研究帕金森病（PD）脑铁沉积，探讨其临床应用价值。方法收集2010年6月～2016年6月于内蒙古医科大学附属医院神经内科诊治的40例帕金森病患者为PD组，另选同期健康志愿者20例为对照组（NC组）。所有PD患者进行Hoehn&Yahr分级，分期≤1.5为早期组（PD1组）23例，分期>1.5为中晚期（PD2组）组17例。采用3.0TMR系统对各组中脑核团行常规MRI平扫和SWI序列扫描，分别测量各核团位相值，并对测量结果进行比较和相关性分析。结果 PD组与NC组双侧尾状核（CN）、苍白球（GP）、双侧壳核（PU）、红核（RN）、黑质（SN）相位值比较均有所增加，提示有较多的铁沉积。PD1组、PD2组与NC组中SN、GP和RN的相位值比较，差异有统计学意义（P < 0.05），但三组PU、CN的相位值比较，差异无统计学意义（P > 0.05）；PD2组SN、GP、CN相位值与NC组比较，差异有统计学意义（P < 0.05），但PD1组与PD2组相位值比较，差异无统计学意义（P > 0.05）。结论 SWI可反映脑内铁沉积，可以通过测量相关脑核团信号强度并计算出相位值以评价脑铁沉积，为PD患者的辅助诊断与治疗提供一定帮助。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	贺娟1 呼日乐特木尔1 韩晓东2 孙明1 张春雨1 段美庆3 王智光1 张国华

关键词 ：磁敏感加权成像, 帕金森病, 铁沉积

Abstract：Objective To clinical value of iron deposition in brain of Parkinson disease (PD) by susceptibility weighted imaging (SWI). Methods From June 2010 to June 2016, in Department of Neurology, Affiliated Hospital of Inner Mongolia Medical University, 40 PD patients were selected as PD group, 20 healthy volunteers were enrolled into the control group (NC group) at the same time. All PD patients were graded by Hoehn&Yahr, stage≤1.5 as early phase group (PD1 group) 23 cases, stage > 1.5 as middle and advanced phase (PD2 group) 17 cases. brain nuclei of each group were examinated by MRI and SWI with 3.0TMR system, and the results were compared and analyzed. Results The phase values of caudate nucleus (CN), globus pallidus (GP), putamen (PU), red nucleus (RN) and substantia nigra (SN) of patients in PD group increased compared with NC group, which indicated there was more iron deposits. The phase values of SN, GP and RN in PD1 group, PD2 group and NC group were compared, the differences were statistically significant (P < 0.05), but the phase values of PU, CN in three groups were compared, the differences were not statistically significant (P > 0.05); the phase values of SN, GP, CN in PD2 group were compared with NC group, the differences were statistically significant (P < 0.05), but these in PD1 group and PD2 group were compared, the differences were not statistically significant (P > 0.05). Conclusion SWI can reflect the iron deposition in the brain, and it can be used to evaluate the brain iron deposition by measuring the signal intensity of related brain nuclei and calculating the phase value. It can provide some help for diagnosis and treatment of the patients.

Key words： Susceptibility-weighted Imaging Parkinson disease Deposition of iron

基金资助:内蒙古自治区自然科学基金面上项目（2014MS 08105）；
内蒙古自治区卫计委科研计划项目（201301056）。

作者简介: 贺娟（1964.12-），女，主任医师，硕士研究生导师；研究方向：脑血管病、帕金森病。

引用本文:

贺娟1 呼日乐特木尔1 韩晓东2 孙明1 张春雨1 段美庆3 王智光1 张国华. 磁敏感加权成像测量脑铁沉积在帕金森病中的临床应用[J]. 中国医药导报, 2017, 14(28): 117-120.
HE Juan1 Huriletemuer1 HAN Xiaodong2 SUN Ming1 ZHANG Chunyu1 DUAN Meiqing3 WANG Zhiguang1 ZHANG Guohua1 LIU Guiying1 . Susceptibility-weighted imaging of clinical application of brain iron depositionin in patients with Parkinson disease. 中国医药导报, 2017, 14(28): 117-120.

链接本文:

http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2017/V14/I28/117

[1] 王书健，邓克学，郑春生，等. SWI测量脑铁沉积在帕金森病中的临床应用价值[J].安徽医科大学学报，2013,48（5）：523-526.
[2] Atasoy HT，Nuyan O，Tunc T，et al. T2-weighted MRI in Parkinson，s disease;Substantia nigra parscompacta hypointensity correlateswwith the clinjical scores [J]. Neurol India，2004，52（3）：332-337.
[3] Lonneke ML，Monique MB. Epidemiology of Parkinson′s disease [J]. Lancet Neurol，2006;5（6）：525-535.
[4] 任延德，龙莉玲，李向荣，等.磁敏感加权成像检测帕金森病患者黑质铁含量[J].广西医学，2016，38（6）：770-772.
[5] Gelb DJ，Oliver E，Gilman S. Diagnostic criteria for Parkinson，s disease [J]. Arch Neurol，1999，56（1）：33-39.
[6] 舒红格，漆剑频.帕金森病的扩散张量成像研究[J].中国医学影像技术，2010，26（4）：643-645.
[7] Kaur D，Peng J，Chinta SJ，et al. Inereased murine neonatal iron intake results in Parkinson-like neurodegeneration with age [J]. Neurobiol Aging，2007，28：907.
[8] 万华，李春华，赵年.磁敏感加权成像技术在帕金森病患者的脑基底节和红核铁含量的变化分析中的应用研究[J].临床和实验医学杂志，2015，14（8）：628-630.
[9] Liu TY，Bai Y，Ma XY，et al. The value of “swallow tail” appearance of nigrosome on ESWAN at 3.0T MR in the diagnosis of Parkinson′s disease [J]. Chin J Magn Reson Imaging，2016，7（46）：265-269.
[10] 王慈，范国光，刘芳，等.磁敏感加权成像中脑定量测量在帕金森病中的初步应用[J].中国医学影像技术，2011， 27（6）：1129-1133.
[11] Yoon RG，Kim SJ，Kim HS，et al. The utility of susceptibility-weighted imaging for differentiating Parkinsonism-predominant multiple system atrophy from Parkinson disease ：correlation with 18F-flurodeox-yglucose positron-emission tomography [J]. Neurosci Lett，2015，1（584）：296-301.
[12] 杨威.脑铁含量与帕金森病的关系分析[J].临床合理用药，2016，9（8）：104-105.
[13] 江名芳，牛广明，高阳，等.帕金森病脑铁沉积的定量研究[J].医学影像学杂志.2016，26（5）：762-767.
[14] Tea-Hyoung Kim， Jae-Hyeok Lee. Serum uric acid and nigral iron deposition in Parkinson′s disease：a pilot study [J]. PLoS One，2014，9（11）：e112512.
[15] Wu SF，Zhu ZF，Kong Y，et al. Assessment of cerebral iron content in patients with Parkinson disease by the susceptibility-weighted MRI [J]. Eur Rev Med Pharmacol Sci，2014，18 （18）：2605-2608.
[16] Zhang J，Wang J. Characterizing iron deposition in Parkinson disease using suseeptibility- weighted imaging：an invivo MR study [J]. Brain Res，2010，13（30）：124-130.
[17] Haacke EM，Cheng YC，Ogg RJ，et al. Imaging iron stores in the brain using magnetic resonance imaging [J]. Magn Reson Imaging，2005，23（1）：1-25.
[18] 杨江胜，朱祖福，高志强，等.磁敏感加权成像在测定帕金森病脑铁沉积中的临床应用[J].中国老年学杂志，2015，35（6）：3368-3369.
[19] 王波，安鸿飞，张杰，等.3.0TMR磁敏感加权成像对早期帕金森病黑质致密带的研究[J].昆明医科大学学报，2014，35（2）：27-30.
[20] Berg D，Hochstrasser H. Iron metabolism in Parkinsonian syndromes [J]. Mov Disord，2006，21：1299-1310.
[21] 王劲.MRI检测帕金森病脑铁含量的研究进展[J].国外医学：神经病学·临床放射学分册，2002，29（6）：556-559.