Comparison study of resuscitation effect of hydroxyethyl starch 130/0.4 electrolyte injection and hydroxyethyl starch 130/0.4 sodium chloride solution in the treatment of septic shock
WANG Liwei LU Yan LI Ruhong
Department of Anesthesia, Affiliated Hospital of Chengde Medical University, Hebei Province, Chengde 067000, China
Abstract：Objective To compare the resuscitation effect of hydroxyethyl starch 130/0.4 electrolyte injection and hydroxyethyl starch 130/0.4 sodium chloride solution on the treatment of septic shock. Methods A total of 92 patients with septic shock in Affiliated Hospital of Chengde Medical University from January 2016 to January 2018 was enrolled in this study. The subjects were divided into the control group (n = 46) and the treatment group (n = 46) according to the random number table method. The control group was treated with hydroxyethyl starch 130/0.4 sodium chloride solution, the treatment group was treated with hydroxyethyl starch 130/0.4 electrolyte injection. The blood gas related indicators (pH value, HCO3-, blood lactic acid), electrolyte indicators (K+, Na+, Cl-, Mg2+), oxidative stress indicators (SOD, GSH-PX, MDA, AOPP), blood coagulation function related indicators (PT, APTT, TT) of the two groups before recovery and 2 h after recovery were compared. The adverse reactions rates of the two groups during the treatment was compared. Results The pH value, SOD, GSH-PX of the two groups 2 h after recovery were significantly higher than before recovery, the HCO3-, blood lactic acid, MDA, AOPP of the two groups were significantly lower than before recovery, and the change range of the treatment group was significantly better than the control group (P < 0.05). The K+ and Mg2+ of the two groups at 2 h after recovery were significantly lower than before recovery, the Na+ and Cl- of the control group were significantly higher than before recovery, the Na+ and Cl- of the treatment group were significantly lower than before recovery, and the Mg2+ of the treatment group was significantly higher than that of the control group, the Na+ and Cl- of the treatment group were significantly lower than those of the control group, the differences were statistically significant (P < 0.05). There was no statistically significant difference in K+ between the two groups 2 h after recovery (P > 0.05). The PT, APTT and TT of the two groups 2 h after recovery were significantly higher than before recovery, but the PT, APTT, TT of the treatment group were significantly shorter than those of the control group (P < 0.05). During treatment, there was no statistically significant difference in the total incidence of adverse reactions between the two groups (P > 0.05). Conclusion Compared with hydroxyethyl starch 130/0.4 sodium chloride solution, hydroxyethyl starch 130/0.4 electrolyte injection for fluid resuscitation in patients with septic shock is help to maintain the body′s electrolyte and acid-base balance, reduce the oxidative stress reaction, correct blood coagulation function disorder with higher safety.
王立维 路艳 李汝泓. 羟乙基淀粉130/0.4电解质注射液与羟乙基淀粉130/0.4氯化钠在感染性休克患者复苏中的对比研究[J]. 中国医药导报, 2019, 16(16): 108-111,128.
WANG Liwei LU Yan LI Ruhong. Comparison study of resuscitation effect of hydroxyethyl starch 130/0.4 electrolyte injection and hydroxyethyl starch 130/0.4 sodium chloride solution in the treatment of septic shock. 中国医药导报, 2019, 16(16): 108-111,128.
2019, Vol. 16 
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