支气管哮喘患者血清中IL-33、S1P的水平及其临床意义

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摘要目的分析支气管哮喘患者血清中白细胞介素-33（IL-33）及1-磷酸鞘氨醇（S1P）的水平及临床意义。方法选择2015年9月～2017年5月汕头大学医学院第二附属医院（以下简称“我院”）就诊的83例支气管哮喘患者，根据喘息控制情况分为急性期组（n = 48）和缓解组（n = 35）；选取我院同期40名健康体检者为对照组。采用酶联免疫吸附法（ELISA）检测血清中IL-33及S1P水平。测定肺功能指标：第一秒用力呼气量（FEV1）、最大呼气峰流速值（PEF）以及第一秒用力呼气量/用力肺活量（FEV1/FVC）值。应用Pearson相关系数分析患者血清IL-33及S1P水平与肺功能指标的相关性。结果急性期组及缓解组患者的血清IL-33、S1P水平均高于对照组，急性期组患者亦高于缓解组患者，差异有统计学意义（均P ＜ 0.05）；急性期组及缓解组患者的肺功能指标FEV1、PEF以及FEV1/FVC均低于对照组，而急性期组患者亦低于缓解组患者，差异有统计学意义（均P ＜ 0.05）。Pearson相关性分析发现，急性期组及缓解组患者的血清IL-33及S1P水平与肺功能指标均呈负相关（r ＜ 0，P ＜ 0.05）。结论支气管哮喘患者血清IL-33、S1P水平显著上升，与肺功能呈负相关，检测血清IL-33、S1P水平有助于支气管哮喘的病情判定。

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	许惠娟宋梅林钊钒

关键词 ：支气管哮喘, 白细胞介素-33, 肺功能, 1-磷酸鞘氨醇

Abstract：Objective To analyze the levels of interleukin 33 (IL-33) and 1- phosphosphingosine (S1P) in serum of patients with bronchial asthma and their clinical significance. Methods From September 2015 to May 2017, 83 patients with bronchial asthma admitted to the Second Affiliated Hospital of Shantou University School of Medicine ("our hospital" for short) were selected and divided into acute stage group (n = 48) and relief group (n = 35) according to the control of wheeze, 40 healthy subjects in our hospital in the same period were selected as the control group. Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of IL-33 and S1P in serum. Lung function measures, forced expiratory volume in the first second (FEV1), maximum peak expiratory flow rate (PEF), and forced expiratory volume/forced vital capacity in the first second (FEV1/FVC). Pearson correlation coefficient was used to analyze the correlation between serum IL-33 and S1P and pulmonary function indexes. Results Serum IL-33 and S1P levels in the acute stage group and the relief group were higher than those in the control group, and the levels in the acute stage group were also higher than those in the relief group, with statistically significant differences (all P ＜ 0.05). Lung function indexes FEV1, PEF and FEV1/FVC in the acute stage group and the relief group were all lower than those in the control group, while those in the acute stage group were also lower than those in the relief group, with statistically significant differences (all P ＜ 0.05). Pearson correlief coefficient analysis results showed that the serum IL-33 and S1P levels in the acute phase group and the remission group were negatively correlated with lung function indicators (r ＜ 0, P ＜ 0.05). Conclusion Serum IL-33 and S1P levels are significantly increased in patients with bronchial asthma, which is negatively correlated with lung function. The detection of serum IL-33 and S1P levels is helpful for the diagnosis of bronchial asthma.

Key words： Bronchial asthma IL-33 Pulmonary function indices 1- phosphosphingosine

基金资助: 广东省基础与应用基础研究专项（广东省自然科学基金项目）（2014A030313105）；
广东省汕头市医疗科技计划项目（20150406）。

作者简介: 许惠娟（1982.9-），女，硕士；研究方向：肺纤维化、支气管哮喘。

引用本文:

许惠娟宋梅林钊钒. 支气管哮喘患者血清中IL-33、S1P的水平及其临床意义[J]. 中国医药导报, 2019, 16(16): 87-90.
XU Huijuan SONG Mei LIN Zhaofan. Serum levels of IL-33 and S1P in patients with bronchial asthma and their clinical significance. 中国医药导报, 2019, 16(16): 87-90.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2019/V16/I16/87

[1] 林江涛，祝墡珠，王家骥，等.中国支气管哮喘防治指南（基层版）[J].中国实用内科杂志，2013，33（8）：615-622.
[2] Wang L，Chen Q，Shi C，et al. Changes of serum TNF-IL-5 and IgE levels in the patients of mycoplasma pneumonia infeetion with or without bronchial asthma [J]. Int J Clin Exp Med，2015，8（3）：3901-3906.
[3] Zhu J. Thelper2 （Th2） celldifferentiation，type 2 innate lymphoid cell（ILC2）development and regulation of interleukin-4（IL-4）and IL-13 production [J]. Cytokine，2015，75（1）：14-24.
[4] 赵晓静，徐喜媛.支气管哮喘患者细胞因子IL-33与IL-27的相关性[J].世界最新医学信息文摘，2017，17（55）：64.
[5] 计玉兵，朱黎明，戴爱国.1-磷酸鞘氨醇与支气管哮喘[J].中华哮喘杂志：电子版，2013，7（5）：361-364.
[6] 戴芳芳，朱黎明，戴爱国.1-磷酸鞘氨醇与肺部疾病的研究进展[J].临床与病理杂志，2015，35（1）：111-117.
[7] Zhao YW，Xu YQ，Wang CL，et al. Clinical significance of serumsphingosine-1-phosphate level in patients with acute attack of bronchial asthma [J]. Chin J Tcm Wm Crit Care，2017，24（2）：177-179.
[8] 常伟，何剑.雾化吸入治疗中度支气管哮喘急性发作的疗效[J].中国老年学杂志，2016，36（9）：2187-2189.
[9] Lang DM. Severe asthma：Epidemiology，burden of illness，and heterogeneity [J]. Allergy Asthma Proc，2015，36（6）：418-424.
[10] 刘金凤.急性发作支气管哮喘应用临床护理路径的效果分析[J].中国现代药物应用，2018，12（3）：123-124.
[11] 陈培，杨恂，张怡.支气管激发试验对支气管哮喘诊断意义研究[J].中国现代医学杂志，2014，24（7）：44-47.
[12] Walsh GM. Anti-IL-4/-13 based therapy in asthma [J]. Expert Opin Emerg Drugs，2015，20（3）：349-352.
[13] Zeng S，Wu J，Liu J，et al. IL-33 Receptor（ST2）Signalling is Important for Regulation of Th2-Mediated Airway Inflammation in a Murine Model of Acute Respiratory Syncytial Virus Infection [J]. Scand J Immunol，2015， 81（6）：494-501.
[14] 窦锡彬，劳传君，唐汉庆，等.N-乙酰半胱氨酸对哮喘模型小鼠Th1/Th2失衡及相关转录因子的影响[J].广东医学，2018，39（17）：2561-2565.
[15] 姚丽敏，高丽.支气管哮喘发病机制研究进展[J].新疆中医药，2017，35（1）：43-46.
[16] Liu Q，Turnquist HR. Controlling the burn and fueling the fire：defining the role for the alarmin interleukin-33 in alloimmunity [J]. Curr Opin Organ Transplant，2016， 21（1）：45-52.
[17] Sorrentino R，Bertolino A，Terlizzi M，et al. B cell depletion increases sphingosine-1-phosphate-dependent airway inflammation in mice [J]. Am J Respir Cell Mol Bio，2015，52（5）：571-583.
[18] 石小岩，廖爱军.1-磷酸鞘氨醇受体的研究进展[J].实用药物与临床，2016，19（4）：506-509.
[19] 陈礼龙，吴琼.白细胞介素17、33及1-磷酸鞘氨醇在支气管哮喘患者血清中的表达及临床意义研究[J].心肺血管病杂志，2018，37（2）：107-111.
[20] Terashita T，Kobayashi K，Nagano T，et al. Administration of JTE013 abrogates experimental asthma by regulating proinflammatory cytokine production from bronchial epithelial cells [J]. Res Res，2016，17（1）：146.
[21] 郑力彬，黄东.1-磷酸鞘氨醇受体的作用机制及研究进展[J].检验医学与临床，2018，15（6）：893-896.
[22] 徐意芹，王春玲，李爽，等.支气管哮喘急性发作期血清S1P的水平及意义[J].微量元素与健康研究，2017，34（5）：30-31.