Effect of Bushen Qiangjin Capsules on interleukin-1β, tumor necrosis factor-α, prostaglandin E2 and serum prostaglandin E2 in synovial fluid of knee osteoarthritis in early and middle stage
LI Hui ZENG Mingzhu ZHANG Yu
Department of Orthopaedics, Guangdong Second Hospital of Traditional Chinese Medicine, Guangdong Province, Guangzhou 510000, China
Abstract：Objective To investigate the effects of Bushen Qiangjin Capsules on interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), prostaglandin E2 (PGE2) in synovial fluid and serum PGE2 of patients with knee osteoarthritis (KOA) in the early and middle stages. Methods From January 2018 to August 2018, 103 patients with KOA in Guangdong Second Hospital of Traditional Chinese Medicine were selected as the research subjects. The patients were divided into control group (n = 51) and research group (n = 52) according to random number table method. The control group was treated with Glucosamine Capsules combined with Sodium Hyaluronate Intra-Articular Injection. The research group was treated with Bushen Qiangjin Capsules on the basis of the control group. The clinical efficacy was compared between the two groups after treatment. The levels of IL-1β, TNF-α, PGE2 in synovial fluid, serum PGE2 and the recovery of knee joint function were compared between the two groups before and after treatment. The occurrence of adverse reactions during treatment were recorded in the two groups. Results The total effective rate of the study group was significantly higher than the control group (P ＜ 0.05). After treatment, the levels of IL-1β, TNF-α and PGE2 in synovial fluid of the two groups were lower than those before treatment, and that in the study group was lower than those in the control group (P ＜ 0.05). No significant difference in the levels of PGE2 in synovial fluid between the two groups after treatment (P ＞ 0.05). The serum PGE2 level of the two groups decreased after treatment, and the study group was lower than that of the control group (P ＜ 0.05). After treatment, the scores of joint function, joint pain, muscle strength, range of motion, flexion deformity and range of motion of the two groups were all increased, and those in the study group were higher than that of the control group (P ＜ 0.05). No adverse reactions was observed in the two groups during the treatment. Conclusion Bushen Qiangjin Capsules is effective in the treatment of KOA patients in the early and middle stages. It can effectively improve the levels of IL-1β, TNF-α in synovial fluid and serum PGE2 in synovial fluid without increasing the incidence of adverse reactions. It has certain clinical value.
李慧 曾明珠 张瑜. 补肾强筋胶囊对早中期膝骨性关节炎滑液中白细胞介素-1■、肿瘤坏死因子-■、前列腺素E2及血清前列腺素E2的影响[J]. 中国医药导报, 2019, 16(15): 119-123.
LI Hui ZENG Mingzhu ZHANG Yu. Effect of Bushen Qiangjin Capsules on interleukin-1β, tumor necrosis factor-α, prostaglandin E2 and serum prostaglandin E2 in synovial fluid of knee osteoarthritis in early and middle stage. 中国医药导报, 2019, 16(15): 119-123.
2019, Vol. 16 
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