The relationship between serum hypoxia-inducible factor-α level and uterine artery hemodynamic parameters in pregnancy-induced hypertension
YANG Yan1 LU Wei1 LIU Mingjuan2 FANG Jianhong1 LI Xiujuan1
1.Department of Obstetrics, Chengyang People′s Hospital of Qingdao City, Shandong Province, Qingdao 266109,China;
2.Department of Obstetrics and Gynecology, the Second Staff Hospital of Wuhan Iron and Steel (Group) Company, Hubei Province, Wuhan 430083, China
Abstract：Objective To investigate the relationship between serum hypoxia-inducible factor-alpha (HIF-α) level and uterine artery hemodynamic parameters in hypertensive disorders of pregnancy. Methods A total of 100 patients with hypertensive disorders of pregnancy admitted in Chengyang People′s Hospital of Qingdao City in Shandong Province ("our hospital" for short) from January 2017 to May 2018 were selected as observation group. According to blood pressure and complications, they were divided into severe preeclampsia group (n = 21), preeclampsia group (n = 35), pregnancy induced hypertension group (n = 44). Another 40 healthy pregnant women who had normal physical examination in our hospital during the same period were selected as control group. The serum level of HIF-α was detected by enzyme-linked immunosorbent assay, hemodynamic parameter was calculated by color Doppler ultrasound. The changes of serum HIF-α and hemodynamic parameter in each group was compared. The correlation between serum HIF-α and hemodynamic parameter was analyzed by Pearson correlation analysis. Results The level of serum HIF-α and hemodynamic parameters in observation group were significantly higher than those in control group, the differences were statistically significant (P < 0.05). The serum level of HIF-α and hemodynamic parameters in severe preeclampsia group and preeclampsia group were significantly higher than those in pregnancy induced hypertension group (P < 0.05), and the above indexes in severe preeclampsia group were higher than those in preeclampsia group (P < 0.05). Pearson correlation analysis showed that the serum HIF-α level of hypertensive disorders of pregnancy was positively correlated with pulsatility index, resistance index, peak systolic velocity/diastolic peak velocity ratio (r = 0.687, 0.652, 0.329, P = 0.000, 0.000, 0.012). Conclusion Serum HIF-α is highly expressed in hypertensive disorders of pregnancy and is closely related to uterine artery hemodynamics. It is speculated that HIF-α may participate in the occurrence and development of hypertensive disorders of pregnancy.
杨燕1 卢伟1 刘明娟2 方建红1 李秀娟1. 血清缺氧诱导因子-■ 水平与妊娠期高血压疾病子宫动脉血流动力学参数的关系[J]. 中国医药导报, 2019, 16(15): 77-80.
YANG Yan1 LU Wei1 LIU Mingjuan2 FANG Jianhong1 LI Xiujuan1. The relationship between serum hypoxia-inducible factor-α level and uterine artery hemodynamic parameters in pregnancy-induced hypertension. 中国医药导报, 2019, 16(15): 77-80.
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2019, Vol. 16 
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