Effects of oxidative stress on fracture healing progress and coagulation function in patients with transcervical fracture
MING Liang1 WANG Aibing1 LIU Sheng1 LI Kunqing1 LUO Zhengqiang2
1.The first Ward of Orthopedics Department, Jianghan Oil Field General Hospital of Hubei, Hubei Province, Qianjiang 433124, China;
2.Department of Orthopedics, Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Hubei Province, Wuhan 430030, China
Abstract：Objective To study the effect of oxidative stress on fracture healing process and coagulation function in patients with transcervical fracture (TF). Methods A total of 118 patients with TF who underwent surgery in Jianghan Oilfield General Hospital of Hubei (“our hospital” for short) from January 2014 to March 2018 was selected as the observation group. Another 120 volunteers who received a physical examination in our hospital during the same period were selected as the control group. The observation group was followed up for 4 months after surgery. The oxidative stress index, coagulation function and coagulation function of patients with different fracture healing progress were detected and compared between the two groups, and the correlation between the indexes was analyzed. Results The total antioxidant capacity (TAC), catalase (CAT) and superoxide dismutase (SOD) levels in the observation group were significantly lower than those in the control group, and the malondialdehyde (MDA) level was significantly higher than that in the control group (P < 0.05). There were no significant differences in prothrombin time, activated partial thromboplastin time and thrombin time between the two groups (P > 0.05). The level of fibrinogen (FIB) in the observation group was significantly higher than that in the control group (P < 0.05). The levels of TAC, CAT and SOD in the 3-month healing group were significantly higher than those in the 4-month healing group and the delayed healing group. The MDA and FIB levels were significantly lower than those in the 4-month healing group and the delayed healing group (P < 0.05). The levels of TAC, CAT and SOD in the 4-month healing group were significantly higher than those in the delayed healing group, and the MDA and FIB levels were significantly lower than those in the delayed healing group (P < 0.05). The TAC, CAT and SOD levels of TF patients were negatively correlated with fracture healing progress and FIB, respectively. MDA was positively correlated with fracture healing progress and FIB (P < 0.05). Conclusion Oxidative stress in TF patients may have certain effects on the progress of fracture healing and coagulation function. It is possible to comprehensively monitor the oxidative stress index of patients, which can help to judge the prognosis of rehabilitation. It is worthy of attention.
明亮1 王爱兵1 刘晟1 李坤庆1 罗政强2. 股骨颈骨折患者氧化应激对骨折愈合进度和凝血功能的影响[J]. 中国医药导报, 2019, 16(15): 65-68,76.
MING Liang1 WANG Aibing1 LIU Sheng1 LI Kunqing1 LUO Zhengqiang2. Effects of oxidative stress on fracture healing progress and coagulation function in patients with transcervical fracture. 中国医药导报, 2019, 16(15): 65-68,76.
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2019, Vol. 16 
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