胃癌组织中轴蛋白、结肠癌转移相关基因1蛋白的表达及临床意义

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摘要目的探讨胃癌组织中轴蛋白（Axin）、结肠癌转移相关基因1（MACC1）蛋白的表达及其与临床病理参数的关系。方法收集山东省青岛市第八人民医院2015年1月～2017年12月胃癌患者手术标本150例胃癌组织，随机抽取其中70例为癌旁组织，利用免疫组织化法检测癌及癌旁组织中Axin、MACC1的表达；分析Axin、MACC1表达与胃癌患者临床病理参数之间的关系及两者的相关性。结果胃癌组织中Axin阳性表达率低于癌旁组织，胃癌组织中MACC1阳性表达率高于癌旁组织，差异均有高度统计学意义（P ＜ 0.01）。Axin、MACC1在胃癌组织中的表达均与胃癌的浸润深度、分化程度、淋巴结转移以及Duke分期有关（P ＜ 0.01），且胃癌组织中Axin表达与MACC1呈负相关（P ＜ 0.05）。结论 Axin的表达降低及MACC1的表达升高都与胃癌发展相关，早期检测两项指标可为预测胃癌进展提供重要依据；Axin与MACC1的表达负相关，两者可能协同导致肿瘤的低分化、高侵袭、高转移性，提示两者可能成为胃癌治疗的潜在靶点。

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	纪雪华1 秦小洁2 齐卫卫3

关键词 ：胃癌, 轴蛋白, 结肠癌转移相关基因1, 临床病理参数

Abstract：Objective To investigate the expression of Axin and metastasis-associated gene 1 in colon cancer in gastric cancer tissues and their correlation with clinicopathological parameters. Methods From January 2015 to December 2017, 150 surgical specimens of patients with gastric cancer in the Qingdao Eighth People′s Hospital, Shandong Province were collected as the gastric cancer tissue and randomly pick one of them 70 cases as the paracancer tissues. The expression of Axin and MACC1 in the cancer and paracancer tissues were detected by immunohistochemistry, to analyze the relationship between the expression of Axin and MACC1 and the clinicopathological parameters of gastric cancer patients and their correlation. Results The positive expression rate of Axin in the gastric cancer tissue was lower than that in the paracancerous tissue, and the positive expression rate of MACC1 in the gastric cancer tissue was higher than that in the paracancerous tissue, the differences were highly statistically significant (P ＜ 0.01). The expressions of Axin and MACC1 in gastric cancer tissues were related to the invasion depth, differentiation degree, lymph node metastasis and Duke stage of gastric cancer (P ＜ 0.01), and the expression of Axin in gastric cancer tissues was negatively correlated with MACC1 (P ＜ 0.05). Conclusion The decreased expression of Axin and the increased expression of MACC1 are both related to the development of gastric cancer. The early detection of these two indicators can provide an important basis for the prediction of the progress of gastric cancer. The expression of Axin is negatively correlated with MACC1, which may synergistically lead to low differentiation, high invasion and high metastasis of the tumor, suggesting that Axin and MACC1 may be potential targets for the treatment of gastric cancer.

Key words： Gastric cancer Axin Metastasis-associated gene 1 in colon cancer Clinicopathological parameters

基金资助:国家自然科学基金资助项目（81602068）。

通讯作者: 齐卫卫（1977.1-），女，博士，副主任医师；研究方向：消化道肿瘤的诊治。

引用本文:

纪雪华1 秦小洁2 齐卫卫3. 胃癌组织中轴蛋白、结肠癌转移相关基因1蛋白的表达及临床意义[J]. 中国医药导报, 2019, 16(14): 92-95.
JI Xuehua1 QIN Xiaojie2 QI Weiwei3. Expression and clinical significance of Axin and metastasis-associated gene 1 in colon cancer protein in gastric cancer tissues. 中国医药导报, 2019, 16(14): 92-95.

链接本文:

http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2019/V16/I14/92

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