Efficacy of Apatinib Mesylate combined with hepatic artery embolization chemotherapy in the treatment of advanced primary liver cancer
CUI Haizhong1 GE Wei2 CAO Dedong2 WU Long3
1.Department of Oncology, Zaoyang First People′s Hospital, Hubei Province, Zaoyang 441200, China;
2.Department of Oncology, Renmin Hospital of Wuhan University, Hubei Province,Wuhan 430060, China
Abstract：Objective To observe the efficacy and safety of Apatinib Mesylate combined with hepatic arterial chemoembolization (TACE) in the treatment of advanced primary liver cancer. Methods From January 2015 to August 2016, 50 patients with advanced primary liver cancer treated in the Department of Oncology, Renmin Hospital of Wuhan University were selected as subjects. By retrospective analysis, patients were divided into combined group and control group, with 25 cases in each group. Patients in the combination group received TACE followed by sequential oral administration of Apatinib Mesylate, while patients in the control group received TACE alone. The clinical remission rate, survival time and incidence of adverse reactions were compared between the two groups. Results The clinical remission rate of the combined group was significantly higher than that of the control group (P ＜ 0.05). The total survival time of the combined group was longer than that of the control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Apatinib Mesylate combined with TACE has the advantages of improving clinical effect, prolonging survival time and good safety in the treatment of patients with advanced primary liver cancer.
崔海忠1 戈伟2 曹德东2 伍龙2. 甲磺酸阿帕替尼联合肝动脉栓塞化疗治疗中晚期原发性肝癌的效果[J]. 中国医药导报, 2019, 16(14): 88-91.
CUI Haizhong1 GE Wei2 CAO Dedong2 WU Long3. Efficacy of Apatinib Mesylate combined with hepatic artery embolization chemotherapy in the treatment of advanced primary liver cancer. 中国医药导报, 2019, 16(14): 88-91.
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2019, Vol. 16 
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