Abstract：Objective To observe the effect of Metoclopramide combined with 5-HT3 receptor antagonists on chemotherapy-induced nausea and vomiting in patients with advanced cancer chemotherapy and observe their side effects. Methods Advanced cancer patients ineffective with Dolastron, Ondansetron, Tropisetron, and Palonosetron in Center of Oncology of Renming Hospital of Wuhan University from October 2016 to May 2018 were selected respectively, with 30 cases in each variety, named group A, B, C, and D group. Then they were treated combined with Metoclopramide. The occurrence of nausea and vomiting and other side effcts in each group were observed. Results There were no statistically significant differences in the effectiveness of the four groups in preventing acute and delayed nausea and vomiting (P ＞ 0.05). The most common side effects of the four groups were headache, constipation, bloating, drowsiness, fatigue, dizziness, and thirst, but they could be alleviated after symptomatic treatment or withdrawal. Conclusion Among advanced cancer patients who were ineffective with 5-HT3 receptor antagonist alone, Metoclopramide combined with Dolastreline, Ondansetron, Tropisetron, and Palonosetron work in some patients and reduces the incidence of side reactions, which has positive clinical significance.
刘远识 陈心 伍龙 徐细明. 胃复安联合5-HT3受体拮抗剂在化疗相关恶心呕吐患者中的疗效分析[J]. 中国医药导报, 2019, 16(14): 83-87.
LIU Yuanshi CHEN Xin WU Long XU Ximing. Observation and analysis of Metoclopramide combined with 5-HT3 receptor antagonist in patients with chemotherapy-induced nausea and vomiting. 中国医药导报, 2019, 16(14): 83-87.
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2019, Vol. 16 
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