Meta analysis of Compound Danshen Dripping Pills combined with Amiodarone in the treatment of arrhythmia
WANG Dandan1,2 HU Yuanhui2▲ SHI Shuai2 WEI Namin1,2
1.Department of Traditional Chinese Medicine, the First Clinical Medical College, Shaanxi University of Traditional Chinese Medicine, Shaanxi Province, Xianyang 712000, China;
2.Department of Cardiovascular, Guangan′men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
Abstract:Objective To systematically evaluate the clinical efficacy and safety of Compound Danshen Dropping Pills combined with Amiodarone in the treatment of arrhythmia. Methods Cochrane Library, CBM, Clinicaltrials.gov, PubMed, Embase, Medline, CNKI, Wanfang database, VIP full-text electronic journals (VIP) were searched by computer, and randomized controlled trials of Compound Danshen Dropping Pills combined with Amiodarone in the treatment of arrhythmia were collected from the database to September 2018. Randomized controlled trials of arrhythmias were performed by two researchers independently according to inclusion and exclusion criteria. Meta analysis was performed by RevMan 5.3 software. Results Finally, 13 studies were included, involving 1178 subjects including 590 patients of Compound Danshen Dripping Pills combined with Amiodarone trenatment and 588 patients of Amiodarone treatment. Compared with Amiodarone alone, Compound Danshen Dripping Pills combined with Amiodarone has better clinical efficacy [RR = 1.21,95%CI(1.16,1.27),P < 0.00 001] and ventricular premature beats [MD = -178.09,95%CI(-201.94,-154.25),P < 0.00 001], atrial premature beats [MD = -119.14,95%CI(-134.21,-104.06),P < 0.00 001], borderline. Sexual premature beats [MD = -54.88, 95%CI(-68.61,-41.59),P < 0.00 001] frequency were reduced, the incidence of adverse reactions was lower [RR = 0.28,95%CI(0.13,0.60),P < 0.00 001], the difference was statistically significant (P < 0.05). Conclusion Compared with Amiodarone alone, Compound Danshen Dropping Pills combined with Amiodarone has more significant clinical effect and higher safety in the treatment of arrhythmia. However, due to the low quality of the included literature, the above conclusions still need to be supported by more high quality randomized controlled trials.
王丹丹1,2 胡元会2▲ 师帅2 魏娜敏1,2. 复方丹参滴丸联合胺碘酮治疗心律失常效果的Meta分析[J]. 中国医药导报, 2019, 16(12): 113-118.
WANG Dandan1,2 HU Yuanhui2▲ SHI Shuai2 WEI Namin1,2. Meta analysis of Compound Danshen Dripping Pills combined with Amiodarone in the treatment of arrhythmia. 中国医药导报, 2019, 16(12): 113-118.