Abstract：Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a group of RNA-binding proteins that play a key role in complex and various biological processes such as RNA splicing, mRNA processing, telomere synthesis, modulation of gene expression, translation of mRNAs. Heteregeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2/B1) is a member of this proteins family. hnRNPA2/B1 abundantly and ubiquitously expresses in most human tissues and has various functions. Researches indicate that hnRNPA2/B1 is abnormally expressed in diverse malignant tumors, and it can modulate the expression of genes, promote the abilities of proliferation and migration, inhibit apoptosis and regulate tumor resistance in tumors. It also shows that hnRNPA2/B1 has important clinical value in the diagnosis, treatment and prognosis of malignant tumors. Therefore, this paper reviews the development of hnRNPA2/B1 in diverse cancers, such as lung cancer, breast cancer, pancreatic cancer, liver cancer and so on.
[1] Li Z，Chen Q，An W，et al. Novel Pathological Role of hnRNPA1（Heterogeneous Nuclear Ribonucleoprotein A1）in Vascular Smooth Muscle Cell Function and Neointima Hyperplasia [J]. Arterioscler Thromb Vasc Biol，2017，37（11）：2182-2194.
[2] He Y，Smith R. Nuclear functions of heterogeneous nuclear ribonucleoproteins A/B [J]. Cell Mol Life Sci，2009，66（7）：1239-1256.
[3] Han SP，Tang YH，Smith R. Functional diversity of the hnRNPs：past，present and perspectives [J]. Biochem J，2010， 430（3）：379-392.
[4] Chen M，Zhang J，Manley JL. Turning on a fuel switch of cancer-nRNP proteins regulate alternative splicing of pyruvate kinase mRNA [J]. Cancer Res，2010，70（22）：8977-8980.
[5] Lemieux B，Blanchette M，Monette A，et al. A Function for the hnRNP A1/A2 Proteins in Transcription Elongation [J]. PLoS One，2015，10（5）：e0126654.
[6] El-Mazny A，Sayed M，Sharaf S. Human telomerase reverse transcriptase messenger RNA（TERT mRNA）as a tumour marker for early detection of hepatocellular carcinoma [J]. Arab J Gastroenterol，2014，15（2）：68-71.
[7] Wang K，Ling T，Wu H，et al. Screening of candidate tumor-suppressor genes in 3p21.3 and investigation，of the methylation of gene promoters in oral squamous cell carcinoma [J]. Oncol Rep，2013，29（3）：1175-1182.
[8] Chen T，Cui P，Chen H，et al. A KH-domain RNA-binding protein interacts with FIERY2/CTD phosphatase-like 1 and splicing factors and is important for pre-mRNA splicing in Arabidopsis [J]. PLoS Genet，2013，9（10）：e1003875.
[9] Tockman MS，Mulshine JL，Piantadosi S，et al. Prospective detection of preclinical lung cancer：results from two studies of heterogeneous nuclear ribonucleoprotein A2/B1 overexpression [J]. Clin Cancer Res，1997，3（12 Pt 1）：2237-2246.
[10] Fielding P，Turnbull L，Prime W，et al. Heterogeneous nuclear ribonucleoprotein A2/B1 up-regulation in bronchial lavage specimens：a clinical marker of early lung cancer detection [J]. Clin Cancer Res，1999，5（12）：4048-4052.
[11] Dowling P，Pollard D，Larkin A，et al. Abnormal levels of heterogeneous nuclear ribonucleoprotein A2B1（hnRNPA2B1）in tumour tissue and blood samples from patients diagnosed with lung cancer [J]. Mol Biosyst，2015，11（3）：743-752.
[12] Dai L，Li J，Tsay JJ，et al. Identification of autoantibodies to ECH1 and HNRNPA2B1 as potential biomarkers in the early detection of lung cancer [J]. Oncoimmunology，2017，6（5）：e1310359.
[13] Xuan Y，Wang J，Ban L，et al. hnRNPA2/B1 activates cyclooxygenase-2 and promotes tumor growth in human lung cancers [J]. Mol Oncol，2016，10（4）：610-624.
[14] Yu PF，Kang AR，Jing LJ，et al. Long non-coding RNA CACNA1G-AS1 promotes cell migration，invasion and epithelial-mesenchymal transition by HNRNPA2B1 in non-small cell lung cancer [J]. Eur Rev Med Pharmacol Sci，2018，22（4）：993.
[15] Hung CY，Wang YC，Chuang JY，et al. Nm23-H1-stabilized hnRNPA2/B1 promotes internal ribosomal entry site（IRES）-mediated translation of Sp1 in the lung cancer progression [J]. Sci Rep，2017，7（1）：9166.
[16] Hu Y，Sun Z，Deng J，et al. Splicing factor hnRNPA2B1 contributes to tumorigenic potential of breast cancer cells through STAT3 and ERK1/2 signaling pathway [J]. Tumour Biol，2017，39（3）：1010428317694318.
[17] Singh R，Gupta SC，Peng WX，et al. Regulation of alternative splicing of Bcl-x by BC200 contributes to breast cancer pathogenesis [J]. Cell Death & Disease，2016，7（6）：e2262.
[18] Wang L，Liu HL，Li Y，et al. Proteomic analysis of pancreatic intraepithelial neoplasia and pancreatic carcinoma in rat models [J]. World J Gastroenterol，2011，17（11）：1434-1441.
[19] Dai S，Jie Z，Huang S，et al. HNRNPA2B1 regulates the epithelial-mesenchymal transition in pancreatic cancer cells through the ERK/snail signalling pathway [J]. Cancer Cell Int，2017，17：12.
[20] Barceló C，Etchin J，Mansour MR，et al. Ribonucleoprotein HNRNPA2B1 interacts with and regulates oncogenic KRAS in pancreatic ductal adenocarcinoma cells [J]. Gastroenterology，2014，147（4）：882-892.
[21] Gu WJ，Liu HL. Induction of pancreatic cancer cell apoptosis，invasion，migration，and enhancement of chemotherapy sensitivity of gemcitabine，5-FU，and oxaliplatin by hnRNP A2/B1 siRNA [J]. Anticancer Drugs，2013，24（6）：566-576.
[22] Cui H，Feng W，Sun Y，et al. Up-regulation and subcellular localization of hnRNP A2/B1 in the development of hepatocellular carcinoma [J]. BMC Cancer，2010，10：356.
[23] Mizuno H，Honda M，Shirasaki T，et al. Heterogeneous nuclear ribonucleoprotein A2/B1 in association with hTERT is a potential biomarker for hepatocellular carcinoma [J]. Liver Int，2012，32（7）：1146-1155.
[24] Chen T，Gu C，Xue C，et al. LncRNA-uc002mbe.2 Interacting with hnRNPA2B1 Mediates AKT Deactivation and p21 Up-Regulation Induced by Trichostatin in Liver Cancer Cells [J]. Front Pharmacol，2017，8：669.
[25] Wang H，Liang L，Dong Q，et al. Long noncoding RNA miR503HG，a prognostic indicator，inhibits tumor metastasis by regulating the HNRNPA2B1/NF-κB pathway in hepatocellular carcinoma [J]. Theranostics，2018：2814-2829.
[26] Deng J，Song C，Feng W，et al. Effects of hnRNP A2/B1 Knockdown on Inhibition of Glioblastoma Cell Invasion，Growth and Survival [J]. Mol Neurobiol，2016，53（2）：1132-1144.
[27] Dai P，Wang Q，Wang W，et al. Unraveling Molecular Differences of Gastric Cancer by Label-Free Quantitative Proteomics Analysis [J]. Int J Mol Sci，2016，17（1）：E69.
[28] Jing GJ，Xu DH，Shi SL，et al. Aberrant expression and localization of hnRNP-A2/B1 is a common event in human gastric adenocarcinoma [J]. J Gastroenterol Hepatol，2011，26（1）：108-115.
[29] Shi X，Ran L，Liu Y，et al. Knockdown of hnRNP A2/B1 inhibits cell proliferation，invasion and cell cycle triggering apoptosis in cervical cancer via PI3K/AKT signaling pathway [J]. Oncol Rep，2018，39（3）：939-950.
2019, Vol. 16 
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