Efficacy and safety of Sitagliptin combined with insulin in the treatment of type 1 brittle diabetes
LIU Jiao1 XING Xiaolei2 ZHANG Min2 LYU Jing1 WAN Meng1 YANG Yang2▲
1.Clinical College, Wuhan University of Science and Technology, Hubei Province, Wuhan 430064, China;
2.Department of Endocrinology, Tianyou Hospital, Wuhan University of Science and Technology, Hubei Province, Wuhan 430064, China
Abstract：Objective To investigate the clinical efficacy and safety of Sigliptin combined with insulin in the treatment of type 1 brittle diabetes mellitus. Methods A total of 80 patients with type 1 brittle diabetes were selected from September 2016 to April 2018 in Tianyou Hospital, Wuhan University of Science and Technology. They were divided into control group and observation group by odd even random method, with 40 patients in each group. The control group was treated with insulin, while the observation group was treated with Sigliptin on the basis of the control group. The course of treatment was three months. The blood sugar index, islet function, incidence of adverse reactions and frequency of hypoglycemia were compared between the two groups. Results There was no significant difference in FBG, 2 h PBG and HbA1c between the two groups before treatment (P ＞ 0.05). After treatment, FBG, 2 h PBG and HbA1c in the two groups were lower than those before treatment (P ＜ 0.05), and PBG, 2 h PBG and HbA1c in the observation group were lower than those in the control group (P ＜ 0.05). There was no significant difference in fasting C-peptide and postprandial 2 h C-peptide between the two groups before treatment (P ＞ 0.05). After treatment, the fasting C-peptide and postprandial 2 h C-peptide in the two groups were higher than those before treatment (P ＜ 0.05), and the fasting C-peptide and postprandial 2 h C-peptide in the observation group were higher than those in the control group (P ＜ 0.05). The incidence of adverse reactions and the frequency of hypoglycemia in the observation group were significantly lower than those in the control group (P ＜ 0.05). Conclusion Insulin can reduce blood sugar and improve islet function in patients with type 1 brittle diabetes mellitus, but the effect of Sitagliptin combined with insulin in the treatment of type 1 brittle diabetes mellitus is more significant, and the occurrence of hypoglycemic events is less, which can stabilize blood sugar well, and the incidence of adverse events is low. It has high safety and is worth promotion in clinic.
刘娇1 邢晓磊2 张敏2 吕晶1 万蒙1 杨杨2▲. 西格列汀联合胰岛素治疗1型脆性糖尿病的效果及安全性[J]. 中国医药导报, 2019, 16(11): 134-137.
LIU Jiao1 XING Xiaolei2 ZHANG Min2 LYU Jing1 WAN Meng1 YANG Yang2▲. Efficacy and safety of Sitagliptin combined with insulin in the treatment of type 1 brittle diabetes. 中国医药导报, 2019, 16(11): 134-137.
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2019, Vol. 16 
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