肿瘤相关巨噬细胞分泌的细胞因子在肿瘤微环境中作用的研究进展

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摘要肿瘤微环境（TME）内含多种细胞以及多种细胞因子，在肿瘤的增殖、侵袭以及转移上都起到了重要的作用。肿瘤相关巨噬细胞（TAMs）作为TME的重要组成部分，主要通过其分泌的细胞因子与肿瘤细胞相互作用，进而调控肿瘤的进展。本文对TAMs分泌的细胞因子在TME中的作用进行概述，包括肿瘤的侵袭、迁移以及血管生成等。靶向TME中TAMs分泌细胞因子进行干预，有望成为肿瘤一种新的治疗策略。

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	刘璐瑶刘可可张雯雯曹娟杜奥博李波

关键词 ：肿瘤相关巨噬细胞, 细胞因子, 肿瘤微环境, 治疗

Abstract：Tumor microenvironment (TME) contains multiple cells and cytokines, which play an important role in tumor proliferation, invasion and metastasis. Tumor-associated macrophages (TAMs), as an important component of TME, mainly interact with tumor cells through the cytokines secreted by them to further regulate tumor progression. In this paper, the role of cytokines secreted by TAMs in TME was summarized, including tumor invasion, migration and angiogenesis. Targeting TAMs secreted cytokines in TME for intervention is expected to be a new therapeutic strategy for tumors.

Key words： Tumor-associated macrophages Cytokines Tumor microenvironment Therapy

基金资助:吉林省科技厅国际科技合作项目（20170414053 GH）；
吉林省教育厅“十三五”科学技术项目（JJKH20170839 KJ）；
吉林省卫生计生委青年科技骨干培养计划项目（2016 Q020）；
吉林省卫生计生科研计划项目（2015Z007）。

通讯作者: 李波（1977.11-），男，博士，副教授，硕士生导师；研究方向：口腔肿瘤的发病机制及干预。

作者简介: 刘璐瑶（1994.3-），女，吉林大学2017级口腔医学专业在读硕士研究生；研究方向：口腔肿瘤的发病机制及干预。

引用本文:

刘璐瑶刘可可张雯雯曹娟杜奥博李波. 肿瘤相关巨噬细胞分泌的细胞因子在肿瘤微环境中作用的研究进展[J]. 中国医药导报, 2019, 16(11): 30-33.
LIU Luyao LIU Keke ZHANG Wenwen CAO Juan DU Aobo LI Bo. Advances in the role of cytokines secreted by tumor-associated macrophages in tumor microenvironment. 中国医药导报, 2019, 16(11): 30-33.

链接本文:

http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2019/V16/I11/30

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