Research progress on gut microbiota and anti-atherosclerosis treatment with Chinese medicine
WU Min1 LIANG Jiaqi2 LIU Longtao3▲
1.Department of General, Guang′anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China;
2.Department of Cardiovascular, Beijing Longfu Hospital, Beijing 100010, China;
3.Department of Cardiovascular, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China
Abstract：Atherosclerosis is the pathological basis of many kinds of cardiovascular and cerebrovascular diseases. With the deepening understanding of the relationship between the alteration of gut microbiota and the parenteral diseases, the connection between the alteration of gut microbiota and arteriosclerosis has been gradually revealed. The new idea of treating atherosclerosis through regulating gut microbiota has been explored. This review aims to explain the relationship between the alteration of gut microbiota and atherosclerosis, as well as its risk factors. Meanwhile, the effect and mechanism of Chinese medicine in anti-atherosclerosis through regulating gut microbiota are introduced in this article.
吴敏1 梁嘉琪2 刘龙涛3▲. 肠道菌群与动脉粥样硬化及中药干预研究进展[J]. 中国医药导报, 2019, 16(11): 23-26.
WU Min1 LIANG Jiaqi2 LIU Longtao3▲. Research progress on gut microbiota and anti-atherosclerosis treatment with Chinese medicine. 中国医药导报, 2019, 16(11): 23-26.
[1] Turnbaugh PJ，Ley RE，Mahowald MA，et al. An obesity-associated gut microbiome with increased capacity for energy harvest [J]. Nature，2006，444（7122）：1027-1031.
[2] Qin J，Li R，Raes J，Arumugam M，et al. A human gut microbial gene catalogue established by metagenomic sequencing [J]. Nature，2010，464（7285）：59-65.
[3] Karlsson FH，F?覽k F，Nookaew I，et al. Symptomatic atherosclerosis is associated with an altered gut metagenome [J]. Nat Commun，2012，3：1245.
[4] Bogiatzi C，Gloor G，Allen-Vercoe E，et al. Metabolic products of the intestinal microbiome and extremes of atherosclerosis [J]. Atherosclerosis，2018，273：91-97.
[5] Koeth RA，Wang Z，Levison BS，et al. Intestinal microbiota metabolism of L-carnitine，a nutrient in red meat，promotes atherosclerosis [J]. Nat Med，2013，19（5）：576-585.
[6] Charach G，Rabinovich A，Argov O，et al. The role of bile acid excretion in atherosclerotic coronary artery disease [J]. Int J Vasc Med，2012，2012：949672.
[7] Zhao L. The gut microbiota and obesity：from correlation to causality [J]. Nat Rev Microbio，2013，11（9）：639-647.
[8] Yang T，Santisteban MM，Rodriguez V，et al. Gut dysbiosis is linked to hypertension [J]. Hypertension，2015，65（6）：1331-1340.
[9] Pluznick JL，Protzko RJ，Gevorgyan H，et al. Olfactory receptor responding to gut microbiota- derived signals plays a role in renin secretion and blood pressure regulation [J]. Pnas，2013，110（11）： 4410-4415.
[10] Khalesi S，Sun J，Buys N，et al. Effect of probiotics on blood pressure：a systematic review and meta-analysis of randomized，controlled trials [J]. Eur J Nutr，2016，57（1）：95-106.
[11] Fu J，Bonder MJ，Cenit MC，et al. The Gut Microbiome contributes to a substantial proportion of the variation in blood lipids [J]. Circ Res，2015，117（9）：817-824.
[12] Karlsson FH，Tremaroli V，Nookaew I，et al. Gut metagenome in European women with normal，impaired and diabetic glucose control [J]. Nature，2013，498（7452）：99-103.
[13] Vrieze A，Out C，Fuentes S，et al. Impact of oral vancomycin on gut microbiota，bile acid metabolism，and insulin sensitivity [J]. J Hepatol，2014，60（4）：824-831.
[14] David LA，Maurice CF，Carmody RN，et al. Diet rapidly and reproducibly alters the human gut microbiome [J]. Nature，2014，505（7484）：559-563.
[15] Duncan SH，Belenguer A，Holtrop G，et al. Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces [J]. Appl Environ Microbiol，2007， 73（4）：1073-1078.
[16] Marques FZ，Nelson EM，Chu PY，et al. High Fibre Diet and acetate supplementation change the gut microbiota and prevent the development of hypertension and heart failure in DOCA-salt hypertensive mice [J]. Circulation，2016，135（10）：964-977.
[17] Lopezgarcia E，Rodriguezartalejo F，Li TY，et al. The Mediterranean-style dietary pattern and mortality among men and women with cardiovascular disease [J]. Am J Clin Nutr，2014，99（1）：172-180.
[18] Courtin CM. Prebiotic and other health-related effects of cereal-derived arabinoxylans，arabinoxylan-oligosaccharides，and xylooligosaccharides [J]. Cri Rev Food Sci，2011，51（2）：178-194.
[19] Derrien M，Je VHV. Fate，activity，and impact of ingested bacteria within the human gut microbiota [J]. Trends Microbiol，2015，23（6）：354-366.
[20] Brandt LJ，Aroniadis OC，Mellow M，et al. Long-term follow-up of colonoscopic fecal microbiota transplant for recurrent Clostridium difficile infection [J]. Am J Gastroenterol，2012，107（7）：1079-1087.
[21] Vrieze A，Van NE，Holleman F，et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome [J]. Gastroenterology，2012，143（4）：913-916.
[22] Wymore MB，Wannemuehler JM，Phillips JG，et al. The altered schaedler flora：continued applications of a defined murine microbial community [J]. Ilar Journal，2015，56（2）：169-178.
[23] Liu CS，Zheng YR，Zhang YF，et al. Research progress on berberine with a special focus on its oral bioavailability [J]. Fitoterapia，2016，109：274-282.
[24] Hsiu SL，Lin YT，Wen KC，et al. A deglucosylated metabolite of paeoniflorin of the root of Paeonia lactiflora and its pharmacokinetics in rats [J]. Planta Medica，2003，69（12）：1113-1118.
[25] 刘玉峰，胡延喜，王志萍，等.肠道菌群对中药有效成分的生物转化研究进展[J].辽宁大学学报：自然科学版，2017，44（4）：325-332.
[26] 门薇，陈颖，杨庆，等.不同配伍戊己丸的黄连生物碱在人源肠道菌群中的代谢研究[J].中国中药杂志，2013， 38（3）：417-421.
[27] 刘晋仙，林永强，汪冰，等.中药促进益生菌生长的研究进展[J].药学研究，2015，34（9）：537-538.
[28] 王广.党参多糖对肠道菌群失调小鼠的调整作用机制的初步研究[D].佳木斯：佳木斯大学，2010.
[29] 张宇，沈宇，胡新俊，等.黄芪多糖对微生态调节作用的物质基础研究初探[J].中国微生态学杂志，2012，24（2）：113-116.
[30] 吴国琳，余国友，卢雯雯.中药复方对肠道微生态的调节作用研究现状[J].中国中药杂志，2015，40（18）：3534-3537.
[31] 罗海燕，宋姗姗，黄暨生，等.黄芩苷对小鼠肠道菌群影响的量-时规律观察[J].中国医药指南，2010，8（32）：42-43.
[32] 谭俊青，潘慧娟，钟力，等.黄连解毒组方颗粒剂对小鼠肠道菌群的影响[J].江西中医药大学学报，2012，24（3）：69-73.
[33] Li H，He C，Wang J，et al. Berberine activates peroxisome proliferator-activated receptor gamma to increase ather-osclerotic plaque stability in Apoe-/- mice with hyperhomocysteinemia [J]. J Diabetes Investig，2016，7（6）：824-832.
[34] 贺凯.黄连生物碱调节高脂C57BL/6J小鼠胆汁酸信号通路和肠道微生物改善血脂异常研究[D].重庆：西南大学，2017.
[35] Kai H，Hu Y，Hang M，et al. Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways [J]. BBA - Mol Basis Dis，2016，1862（9）：1696-1709.
[36] Zhang X，Zhao Y，Xu J，et al. Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats [J]. Sci Rep-UK，2015，5：14405.
[37] Wang JH，Bose S，Kim GC，et al. Flos Lonicera ameliorates obesity and associated endotoxemia in rats through modulation of gut permeability and intestinal microbiota [J]. PLoS One，2014，9（1）：e86117.
[38] Chang CJ，Lin CS，Lu CC，et al. Corrigendum：Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota [J]. Nat Commun，2017，8：16130.
[39] Xu J，Lian F，Zhao L，et al. Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula [J]. Isme J，2015，9（3）：552-562.
[40] 章常华，马广强，邓永兵，等.葛根芩连汤对KK-Ay糖尿病小鼠血浆中LPS、TNF-α、IL-6及肠道菌群的影响[J].中草药，2017，48（8）：1611-1616.
2019, Vol. 16 
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