Analysis on medication rule of Chinese medicine in treating precocious puberty based on data mining technology
LIU Zhiwei1 LIU Lujia1 JING Weichao2 QU Wanying3 WANG Youpeng2
1.The Second Clinical Medical College, Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China;
2.Department of Pediatrics, the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150001, China; 3.Department of Pediatrics, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China
Abstract：Objective To dig out the characteristics and rules of Chinese medicine in treating precocious puberty, and extract new prescriptions. Methods Through retrieving CNKI, Wanfang Data Knowledge Service Platform, and VIP database on therapeutic precocious puberty of Chinese medicine from January 1, 1979 to October 1, 2018. And TCM inheritance support system was used to carry on the statistics analysis. Results Total 104 articles and 124 prescriptions were included in the reseach. It was concluded that the most frequently used drugs were Anemarrhena asphodeloides, Phellodendron amurense, Peony bark, Poria cocos, Rehmannia glutinosa and Paeonia lactiflora. Based on the association rules, the potential prescriptions have got. And then 22 core combinations of 3 flavors, 10 core combinations and 5 new prescriptions were explored from the database. Conclusion This study analyzes the prescription rule of Chinese medicine for treating precocious puberty, and obtains new prescriptions with the main principles of enrich liver and kidney, nourish yin and clear heat, boost qi and promote fluid and move qi and dissipate binds, which provides the basis for the clinical treatment of this disease by Chinese medicine, and also provides a reference for the development of new drugs for this disease.
刘志伟1 刘璐佳1 景伟超2 曲婉莹3 王有鹏2. 基于数据挖掘中药治疗性早熟的用药规律研究[J]. 中国医药导报, 2019, 16(10): 120-123,136.
LIU Zhiwei1 LIU Lujia1 JING Weichao2 QU Wanying3 WANG Youpeng2. Analysis on medication rule of Chinese medicine in treating precocious puberty based on data mining technology. 中国医药导报, 2019, 16(10): 120-123,136.
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2019, Vol. 16 
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