反流性食管炎与代谢综合征相关因素的关系

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摘要目的探讨反流性食管炎（RE）与代谢综合征相关因素的关系。方法选取2016年11月~2018年3月于武汉大学人民医院内镜中心行胃镜检查并确诊为RE的患者176例作为RE组，选取同期胃镜检查正常或仅有轻度慢性浅表性胃炎的患者331例作为对照组。收集其一般信息、既往史。两组均行腹部超声检查及血生化检验。分析两组年龄、性别、体重指数（BMI）、非酒精性脂肪性肝病（NAFLD）检出率、吸烟率、高血压患病率、血糖、血脂等差异及RE发生的独立危险因素。结果 RE组的男性占比、BMI、NAFLD检出率、吸烟率、高血压患病率及丙氨酸转移酶、空腹血糖、三酰甘油水平明显高于对照组（P < 0.05），高密度脂蛋白水平明显低于对照组（P < 0.05）；其中男性、超重、高血压是RE的独立危险因素（OR = 2.274，3.389，2.145，P < 0.05）。结论男性、超重、高血压是RE发病的危险因素，在临床防治中应予以重视。

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	程怡安谭诗云李明陆明军

关键词 ：反流性食管炎, 代谢综合征, 非酒精性脂肪性肝病, 超重, 高血压, 危险因素

Abstract：Objective To investigate the relationship between reflux esophagitis (RE) and related factors of metabolic syndrome. Methods From November 2016 to March 2018, 176 patients who underwent endoscopy at the endoscopy center of Renmin Hospital of Wuhan University and were diagnosed with RE were enrolled as RE group. And 331 patients with normal gastroscopy or only mild chronic superficial gastritis in the same period were selected as control group. General information and past history were collected. Abdominal ultrasonography and blood biochemical tests were performed in both groups. The differences of age, sex, body mass index (BMI), detection rate of nonalcoholic fatty liver disease (NAFLD), smoking rate, prevalence rate of hypertension, blood sugar, blood lipid and other independent risk factors between the two groups and the independent risk factors for RE were analyzed. Results The percentage of males, BMI, NAFLD detection rate, smoking rate, prevalence of hypertension, alanine transferase, fasting blood sugar and triglyceride levels in RE group were significantly higher than those in the control group (P < 0.05), and the level of high density lipoprotein was significantly lower than that in the control group (P < 0.05). Male, overweight and hypertension were independent risk factors for RE (OR = 2.274, 3.389, 2.145, P < 0.05). Conclusion Male, overweight and hypertension are the risk factors of RE, which should be paid attention to in clinical prevention and treatment.

Key words： Reflux esophagitis Metabolic syndrome Nonalcoholic fatty liver disease Overweight Hypertension Risk factors

基金资助:中央高校基本科研业务费专项资金项目（20420 17kf0092）。

通讯作者: 谭诗云（1962.10-），男，博士，教授，博士生导师；研究方向：胃食管疾病。

作者简介: 程怡安（1993.12-），女，武汉大学2016级内科学专业在读硕士研究生；研究方向：胃食管疾病。

引用本文:

程怡安谭诗云李明陆明军. 反流性食管炎与代谢综合征相关因素的关系[J]. 中国医药导报, 2019, 16(10): 92-95.
CHENG Yi′an TAN Shiyun LI Ming LU Mingjun. Relationship between reflux esophagitis and related factors of metabolic syndrome. 中国医药导报, 2019, 16(10): 92-95.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2019/V16/I10/92

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