Progress of TSG-6 in repairing cartilage and promoting tendon-bone healing
XU Zhi1,2 LIU Yi1,2▲ ZOU Gang1,2
1.Zunyi Medical College-Rochester University Orthopaedic Research Center, Guizhou Province, Zunyi 563000, China;
2.Department of Orthopaedics, Zunyi Medical College Affiliated Hospital, Guizhou Province, Zunyi 563000, China
Abstract：Locomotor system injuries includes the injuries of tendons, ligaments, cartilage and other soft tissue injuries, which is a common disease in young adults in China. Because the original tissue regeneration ability is weak, scar formation and local inflammation evolution increase the risk of later traumatic arthritis. The ability of the original tissue regeneration is weak, leading to scar formation and local inflammation evolution, which increase the risk of later traumatic arthritis. At present, the use of growth factor intervention for the treatment of locomotor system injury is more popular. TSG-6 was found to regulate the response of injury signals to reduce inflammation, prevent the formation of fibrous vascular tissue, improve the structure and adhesion strength of the healing tendon-bone interface, which promotes cartilage formation and tendon-bone healing. This paper will elaborate on the study of TSG-6 inhibition of scar formation, promotion of tendon-bone healing, and protection of cartilage.
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2019, Vol. 16 
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