Clinical effect of needle-knife in the treatment of knee osteoarthritis
HONG Hanqing1 ZHANG Cairong2 CHEN Dechun3 HUA Zhijuan3 WANG Pei1 RUAN Zhizhong2
1.Graduate School, Nanjing University of Chinese Medicine, Jiangsu Province, Nanjing 210000, China;
2.Department of Acupuncture and Moxibustion, Nanjing Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Jiangsu Province, Nanjing 210000, China;
3.Daishan Community Health Service Center of Yuhuatai District in Nanjing City, Jiangsu Province, Nanjing 210000, China
Abstract：Objective To observe the clinical effect of needle-knife therapy for patients with knee osteoarthritis, and to evaluate the effectiveness and safety of needle-knife in the treatment of knee osteoarthritis. Methods From October 2017 to April 2018, 61 patients with knee osteoarthritis admitted to Nanjing Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine and Daishan Community Health Service Center of Yuhuatai District in Nanjing City were randomly divided into the needle-knife group (31 cases) and the acupuncture group (30 cases) by random number table method. In the needle-knife group, the positive reaction points around the knee joint were selected for needle-knife treatment, once a week, totally for 3 times; in the acupuncture group, routine acupoints were selected for acupuncture treatment, once a day, 5 times each week, totally for 3 weeks. The Western Ontario and McMaster University Osteoarthritis Survey Scale (WOMAC) questionnaire, visual analogue scale (VAS), the levels of nitric oxide (NO), interleukin 1β (IL-1β), transforming growth factor (TGF-β1) in joint fluid were measured at the time of enrollment and the end of treatment. Results In the two groups, 30 patients completed the course of treatment, one patient in the needle-knife group fell off. In terms of WOMAC score, the needle-knife group and the acupuncture group were both significantly decreased at the first week, the 3rd week, and one month after treatment (P ＜ 0.05 or P < 0.01). The needle-knife group was better than the acupuncture group at the 3rd week and one month after treatment (P ＜ 0.05). In terms of VAS score, the needle-knife group was significantly decreased at the first week, the 3rd week, and one month after treatment (P ＜ 0.01), the acupuncture group was significantly decreased at the 3rd week of treatment and one month after treatment (P ＜ 0.05). The needle-knife group was superior to the acupuncture group at the first week and the 3rd week of treatment (P ＜ 0.05 or P < 0.01). At the 3rd week of treatment, the levels of NO and IL-1β in joint fluid of both groups increased (P ＜ 0.05), the level of TGF-β1 decreased (P ＜ 0.05), and the needle-knife group was superior to the acupuncture group (P ＜ 0.05). In terms of total efficiency, the needle-knife group was superior to the acupuncture group (P ＜ 0.05). Conclusion Needle-knife therapy has a good curative effect on the knee osteoarthritis, and the mechanism may be related to its regulation of the levels of NO, IL-1β and TGF-β1 in the joint fluid.
2019, Vol. 16 
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