Abstract：Objective To observe the clinical efficacy of thunder fire moxibustion in the treatment of insomnia patients with liver qi stagnation and yin deficiency syndrome. Methods A total of 80 patients diagnosed as insomnia with liver qi stagnation and yin deficiency syndrome in Sleep Clinic Outpaitient, Guangdong Provincial Hospital of Chinese Medicine, were recruited and they were divided into thunder fire moxibustion group and medicine group by random number table method, with 40 cases in each group. The thunder fire moxibustion group received thunder fire moxibustion treatment. The medicine group was given 1mg Estazolam half an hour before bedtime per night. The two groups were treated once a day and after 1 month′s continous treatment, the efficacy of treating insomnia were observed in the two groups. Pittsburgh sleep quality index (PSQI) score, self-rating anxiety scale (SAS) score, average weekly insomnia days and Epworth sleepiness scale (ESS) score as well as adverse reactions were recorded. Results After one month′s treatment, the thunder fire moxibustion group had better clinical efficacy and less adverse reactions compared to the medicine group (P ＜ 0.05 or P ＜ 0.01). Compared with before treatment, PSQI and SAS scores were lower after treatment in the thunder fire moxibustion group (P ＜ 0.05), while PSQI and SAS scores in the medicine group had no statistically significant difference before and after treatment (P ＞ 0.05). After treatment, PSQI and SAS scores in the thunder fire moxibustion group were lower than the medicine group, the difference was statistically significant (P ＜ 0.05). After treatment, the average weekly insomnia days of thunder fire moxibustion group and medicine group were less than that before treatment, and the difference were statistically significant (P ＜ 0.05). Compared with the medicine group, the average weekly insomnia days of thunder fire moxibustion group were less in the thunder fire moxibustion group, and the difference was statistically siginificant (P ＜ 0.05). After treatment, the ESS scores of the two groups were less than those before treatment, the difference was statistically significant (P ＜ 0.05). And after treatment, the ESS scores of the thunder fire moxibustion group was less than that of the medicine group, the difference was statistically significant (P ＜ 0.05). Adverse reaction rate in the thunder fire moxibustion group was lower than that in the medicine group, and the difference was highly statistically significant (P ＜ 0.01）. Conclusion Thunder fire moxibustion can effectively improve the symptoms of insomnia patients with liver qi stagnation and yin deficiency syndrome with less adverse reactions, which is worthy of clinical promotion.
吴少霞 刘真真 李思逸. 雷火灸治疗肝郁阴虚型失眠的临床效果[J]. 中国医药导报, 2019, 16(9): 149-153.
WU Shaoxia LIU Zhenzhen LI Siyi. Clinical efficacy of thunder fire moxibustion on insomnia with liver qi stagnation and yin deficiency syndrome. 中国医药导报, 2019, 16(9): 149-153.
[1] Ohayon MM. Epidemiology of insomnia：what we know and what we still need to learn [J]. Sleep Med Rev，2002，6（2）：97-111.
[2] Soldatos CR，Allaert FA，Ohta T，et al. How do individuals sleep around the world? Results from a single-day survey in ten countries [J]. Sleep Med，2005，6（1）：5-13.
[3] Roth T，Jaeger S，Jin R，et al. Sleep problems，comorbid mental disorders，and role functioning in the national comorbidity survey replication [J]. Biol Psychiatry，2006，60（12）：1364-1371.
[4] 周仲瑛.中医内科学[M].北京：中国中医药出版社，2007：146-147.
[5] 董偓，陈振锋.针灸推拿治疗失眠症60例临床分析[J].中国现代医生，2011，49（3）：122，135.
[6] 郑筱萸.中药新药临床研究指导原则[M].北京：中国医药科技出版社，2002：201-206.
[7] 美国精神医学学会.精神障碍诊断与统计手册（第5版）[M].北京：北京大学出版社，2015：352-358.
[8] Johns MW. A new method for measuring daytime sleepiness：the Epworth sleepiness scale [J]. Sleep，1991，14（6）：540-545.
[9] 黄希翘，陈春红.失眠从肝论治的临床探讨[J].当代医学，2012，19（25）：150-151.
[10] 李雪晶，郭轶，傅春恋，等.青老年失眠患者睡眠脑电图的对照研究[J].齐齐哈尔医学院学报，2014，25（10）：1429-1430.
[11] 徐波，王平，游秋云，等.老年失眠的中医发病机制及防治探讨[J].世界睡眠医学杂志，2016，4（1）：29-31.
[12] 夏丽娜.赵氏雷火灸治疗心肾不交型失眠60例临床观察[J].实用中医内科杂志，2016，30（1）：95-97.
[13] 陈盼碧，邹君，王士嘉，等.雷火灸对膝骨性关节炎模型大鼠抗炎作用的实验研究[J].光明中医，2017，24（5）：647-679.
[14] 马铎.心俞肾俞穴为主治疗失眠50例[J].内蒙古中医药，2011，27（16）：38-39.
[15] 刘思娣，刘洋，丁然然，等.艾灸心俞、肾俞穴对大学生睡眠障碍的影响[J].中国民间疗法，2016，24（1）：13-14.
[16] 薛文雄，张金嫒，葛玲玲，等.针刺联合雷火灸治疗更年期失眠疗效观察[J].按摩与康复医学，2017，8（3）：25-26.
[17] 杨菲，王济，孙淑娴，等.从《灵枢·经脉》浅谈气郁质相关疾病的治疗[J].时珍国医国药，2015，26（6）：1437-1438.
[18] 黄凯裕，梁爽，许岳亭，等.基于数据挖掘的针灸治疗失眠选穴规律分析[J].中国针灸，2015，35（9）：960-963.
[19] 马恰怡，李艳，曹莲瑛.试述失眠从督脉论治[J].江苏中医药，2014，46（5）：9-10.
[20] 王秀，冯学功.浅谈阳虚失眠证治[J].河北中医，2014，36（5）：692-693.
[21] 贾玉，贾跃进，郑晓琳.中医对失眠认识的探讨及展望[J].中华中医药杂志，2015，30（1）：163-166.
[22] 罗海鸥，李绍旦，杨明会.杨明会教授从“胃”论治失眠理论探析[J].中华中医药杂志，2013，28（2）：423-425.
[23] 杨舟，冯国香，张国山，等.中医“治未病”思想指导下艾灸应用的现状和意义[J].吉林中医药杂志，2013，33（8）：841-843.
[24] 苏丽萍，张巍，何继华，等.百乐眠口服结合物理刺激治疗肝郁阴虚型不寐的有效性与安全性分析[J].现代中药研究与实践，2016，25（6）：68-71.
[25] 杨璐瑜，张选国.针刺联合百乐眠胶囊治疗肝郁阴虚型失眠疗效观察[J].陕西中医，2017，38（2）：256-258.
2019, Vol. 16 
京公网安备 11010502046598号