Abstract:Objective To investigate the changes of white blood count (WBC), lactic acid (Lac), platelet count (PLT) and arterial oxygen pressure (PaO2) in patients with urinary obstructive sepsis and its significance. Methods From January 2017 to June 2018, 68 patients with urinary obstructive sepsis (observation group) in the Fourth Hospital of Changsha were selected as the observation group, and 70 cases of urinary tract infection were selected as control group, the levels of WBC, Lac, PLT and PaO2 were detected, the prognosis was evaluated by chronic health evaluation Ⅱ (APACH Ⅱ). Results The WBC, Lac in the observation group at 6 h in the onset of disease were significantly higher than those in the control group (P < 0.05), while PLT and PaO2 were significantly lower than those of the control group (P < 0.05); the WBC, Lac in the observation group at 24 h in the onset of disease were significantly higher than those in 6 h and 12 h (P < 0.05); the PLT, PaO2 in the observation group at 12 h in the onset of disease were significantly lower than that in 6 h and 24 h (P < 0.05). There were positive correlations between WBC and acute physiological and APACH Ⅱ in the onset of 6 h (r = 0.422, P < 0.05), and PLT, PaO2 were negatively correlated with APACH II (r = -0.341, -0.336, P < 0.05). Conclusion The levels of WBC, Lac in patients with urinary obstructive sepsis are elevated, while the levels of PLT and PaO2 are decreased, and the levels of WBC, PLT and PaO2 are related to the severity of the patients.