Abstract:Objective To evaluate the efficacy and safety of Lianhua Qingwen Capsules in the treatment of community acquired pneumonia. Methods Medline, The Cochrane Libary, PubMed, Wanfang Database, VIP database, CNKI and CBM were searched to collect the randomized controlled trials on Lianhua Qingwen Capsule combined with conventional western medicine therapy in treating community acquired pneumonia from built library to December 2016. The studies were screened according to the inclusion and exclusion criteria, the quality of the literature was evaluated by reference to the Jadad score method, and Meta-analysis was performed by Rev Man 5.3 software. Results A total of 6 randomized controlled trials were included. The effective rate of combined treatment with Lianhua Qingwen Capsule was significantly higher than that of western medicine treatment alone (OR = 1.70, 95%CI: 1.15-2.52, P=0.008), the antipyretic time (WMD = -2.33, 95%CI: -2.52 - -2.13, P < 0.00 001), cough alleviated time (WMD = -2.63,95%CI: -2.84 - -2.41, P < 0.00001), imaging outcome time (WMD = -1.95,95%CI: -2.73 - -1.18, P < 0.00 001) were significantly shorter than those of western medicine treatment alone, the difference between the two groups were statistically significant. Two studies reported adverse reactions, and there was no statistically significant difference between the combined treatment with Lianhua Qingwen Capsules and the treatment of western medicine alone (P > 0.05). Conclusion Lianhua Qingwen Capsules combined treatment for patients with community acquired pneumonia can improve the effective rate, shorten the time of symptom relief, image outcome, less adverse reactions, and has a good adjuvant effect on community acquired pneumonia. Due to the quality and quantity of the literature, the above conclusions still need to expand the sample size, select the high quality literature for further verification.
周珍 王素美 刘艳萍. 连花清瘟胶囊辅助治疗社区获得性肺炎效果及安全性的Meta分析[J]. 中国医药导报, 2017, 14(33): 133-137.
ZHOU Zhen WANG Sumei LIU Yanping. A Meta-analysis of the effect and safety of Lianhua Qingwen Capsules in the treatment of community acquired pneumonia. 中国医药导报, 2017, 14(33): 133-137.