Abstract：Objective To investigate the significance of mismatch repair/microsatellite instability (MSI) in the chemotherapy sensitivity and prognosis of late-stage colorectal cancer (CRC). Methods From December 2009 to December 2016, in Affiliated Hospital of Yangzhou University, 181 primary tumor tissues were collected from CRC patients who received first-line chemotherapy (FOLFOX or XELOX). Immunohistochemistry was used to detect the expression of MLH1, PMS2, MSH2 and MSH6 in tumor tissues. Based on the staining results, they were divided into MSI group (18 cases) and microsatellite stability (MSS) group (163 cases). The intergroup difference in chemotherapy sensitivity and prognosis were analyzed. Results Except for tumor location (P < 0.05), the differences were not statistically significant in clinical features between two groups (P > 0.05). Kaplan-Meier model was used to analyze follow-up data, there was no statistically significant difference in patient prognosis of two groups (P > 0.05). In chemotherapy sensitivity, there was no statistically significant difference in the total effective rate of two groups (P > 0.05). However, disease control rate of MSI group was significant higher than MSS group, the difference was statistically significant (P < 0.05). Conclusion Although MSI status is not related with the prognosis of late-stage CRC patients, but it is correlated with disease control rate. Therefore, MSI can act as an important marker for evaluating the chemotherapy efficacy in late-stage CRC patients.
王丽 毛海燕 童建东 汪竹▲. 错配修复/微卫星不稳定性对晚期结直肠癌化疗敏感性及预后的影响[J]. 中国医药导报, 2019, 16(8): 108-111,127.
WANG Li MAO Haiyan TONG Jiandong WANG Zhu▲. Significance of mismatch repair/microsatellite instability in the chemotherapy sensitivity and prognosis of late-stage colorectal cancer. 中国医药导报, 2019, 16(8): 108-111,127.
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2019, Vol. 16 
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