Abstract:Objectives To discussion of liver fibrosis index [Ⅲ type collagen (PCⅢ), collagen type Ⅳ before (Ⅳ-C), laminin (LN), hyaluronic acid (HA), gansu cholic acid (CG)], alpha fetal protein (AFP) and γ- glutamyl transpeptidase (GGT) in the diagnosis of liver disease. Methods From July 2017 to June 2018, in Chenzhou NO.1 People′s Hospital of Hunan Province ("our hospital" for short), 90 cases of chronic HBV (carry HBV group), 66 patients with cirrhosis of the liver (cirrhosis group) and 52 patients with hepatitis B related liver cancer (HBV-related liver cancer group), 60 cases (healthy control group) health physical examination were selected from the same period. The liver fibrosis indexes PCⅢ, Ⅳ-C, LN and HA, CG and AFP and GGT of each groups were detected by automatic chemiluminescence analyzer and biochemical analyzer respectively. Results PCⅢ, Ⅳ-C, HA, CG and AFP in the three groups were all higher than those in the healthy control group, and the difference were highly statistically significant (P < 0.01). LN and GGT of liver cirrhosis group and HBV-related liver cancer group were higher than that of healthy control group, and the difference were statistically significant (P < 0.05). There was no significant difference in LN and GGT between the chronic HBV carrier group and the healthy control group (P > 0.05). HA, CG and AFP were compared among the groups, and the difference were statistically significant (P < 0.05). Conclusion Liver fibrosis indicators PCⅢ, Ⅳ-C, LN, HA, CG, GGT and AFP have great application value in the diagnosis of liver disease, and have important value in guiding clinical treatment.
李章勇1 林应标1▲ 夏川1 李刚勇2. 肝纤维化指标联合AFP、GGT检测在肝病诊断中的应用价值[J]. 中国医药导报, 2019, 16(7): 153-156.
LI Zhangyong1 LIN Yingbiao1▲ XIA Chuan1 LI Gangyong2. Application value of liver fibrosis indexes combined with AFP and GGT in the diagnosis of liver diseases. 中国医药导报, 2019, 16(7): 153-156.